Beside the standard grant research projects are the individual research groups of Institute of Physiology CAS involved in the solving the prestigious Centers of Excellence (GA ČR) and the Center of Competence (TA ČR). These projects represent a consortium of several teams focused on innovative research in the field. Institute of Physiology is involved in the role of co-recipient in project "Center for Development of Original Drugs" (2012-2019).

Institute of Physiology is the main coordinator of the programs "QUALITAS - Wellbeing in health and disease" (2015-2020) and "Preclinical testing of potential pharmaceuticals" (2017-2021) which are the part of the Strategy of Czech Academy of Sciences AV21: "Top research in the public interest".