Department of Syntheses IIC
Scope
The topics in the Department is represented by fundamental research on boron clusters, but its results are traditionally devoted also to search for practical implications of these interesting compounds. Boron chemistry in Řež has been gradually developping since early 1960's, in fact; it hence forms one of cornerstones of the Institute of Inorganic Chemistry. Over decades of systematic research initiated by group fathers, J. Plešek, S. Heřmánek and B. Štíbr, the Group continues to develop synthetic routes to new boranes, carboranes, hereroboranes and metallacarboranes, along with development of NMR, HPLC and MS methods for compound's separation and characterization. The practical applications iclude in particular entries into fields of radionuclide extraction, medicinal and material chemistry.
- 11-vertex clusters with three or more cage heteroatoms as analogues of cyclopentadienyl anion (Prize of Academy of Sciences of CR in 2006)
- boranes an carboboranes as low-nucleophilic weakly-coordinating anions
- modified metallacarboranes as robust extracting agents for separation of radionuclides from spent nuclear fuel
- carborane and metallacarborne derivatives with virostatic and cytostatic activity
- chemistry of macropolyhedral boranes
- surface modification of gold and silver surface by carborane and borane thiols
The topics are listed with more details in the section Research
People
Name | Department | Phone | |
---|---|---|---|
Bakardjiev Mario, Ing. | Dpt. Syntheses | 311236947 | mario@iic.cas.cz |
Baše Tomáš, Mgr., Ph.D. | Dpt. Syntheses | 311236933 | tbase@iic.cas.cz |
Bavol Dmytro, Mgr., Ph.D. | Dpt. Syntheses | 311236993,311236963 | bavol@iic.cas.cz |
Bould Jonathan, Ph.D. | Dpt. Syntheses | 311236953 | bould@iic.cas.cz |
El Anwar Suzan, Ph.D. | Dpt. Syntheses | 311236938 | elanwar@iic.cas.cz |
Grüner Bohumír, RNDr., CSc., vedoucí | Dpt. Syntheses | 311236938 | gruner@iic.cas.cz |
Hnyk Drahomír, RNDr., CSc., DSc. | Dpt. Syntheses | 311236926 | hnyk@iic.cas.cz |
Holub Josef, RNDr. | Dpt. Syntheses | 311236999 | holub@iic.cas.cz |
Kaněrová Irena, Ing., vedoucí | Dpt. Syntheses | 311236966 | kanerova@iic.cas.cz |
Londesborough Michael, Ph.D. | Dpt. Syntheses | 311236953 | michaell@iic.cas.cz |
Macháček Jan, Mgr., PhD. | Dpt. Syntheses | 311236955 | jmach@iic.cas.cz |
Štíbr Bohumil, Ing., DrSc. | Dpt. Syntheses | 311236947 | stibr@iic.cas.cz |
Tok Leonidovich Oleg, Dr. | Dpt. Syntheses | 311236948 | tok@iic.cas.cz |
Projects
Title | Recipient | Principal investigator |
---|---|---|
Borane clusters for nanostructured interfaces of materials in electronic applications | Katchem | Baše Tomáš |
New drug delivery systems to cross biological barriers based on the unique properties of carboranes | UP | Grüner Bohumír |
GEN IV Intergrated Oxide fuels recycling strategies | CEA | Grüner Bohumír |
Getting stronger together: exo-substituted feteroboranes and their adducts as suitable motifs for exploration of non-covalent interactions | ÚACH | Hnyk Drahomír |
Boron Hydride Cluster Lasers: Understanding the Chemical and Structural Factors that Determine the Photophysics of anti-B18H22 and its Derivatives | ÚACH | Londesborough Michael |
Ten-vertex dicarbaborane molecular assemblies via alkylation | ÚACH | Štíbr Bohumil |
New family of helicenes based on fused silacyclopentadienes | ÚACH | Tok Oleg |
Equipment
Department has several laboratories completely equipped for synthesis of boron clusters including the work in an inert atmosphere. Newly prepared compounds are characterised using own HPLC with UV-Vis or MS, GC-MS and NMR.
Most cited papers
- Plešek J.: Potential Applications of the Boron Cluster Compounds, Chem. Rev., 92(2), 269—278, 1992
- Štíbr B.: Carboranes Other than C2B10H12, Chem. Rev., 92(2), 225—250, 1992
- King B. T., Janoušek Z., Grüner B., Trammell M., Noll B. C., Michl J.: Dodecamethylcarba-closo-dodecaborate- anion, CB11Me12-, J. Am. Chem. Soc., 118(13), 3313—3314, 1996
- Jelínek T., Plešek J., Heřmánek S., Štíbr B.: Chemistry of Compounds with the 1-carba-closo-dodecaborane(12) Framework, Collect. Czech. Chem. Commun., 51(4), 819—829, 1986
- Plešek J., Jelínek T., Drdáková E., Heřmánek S., Štíbr B.: A Convenient Preparation of 1-CB11H12- and its C-amino Derivatives, Collect. Czech. Chem. Commun., 49(7), 1559—1562, 1984
- From nonpeptide toward noncarbon protease inhibitors: Metallacarboranes as specific and potent inhibitors of HIV protease, Cígler P., Kožíšek M., Řezáčová P., Brynda J., Otwinowski Z., Pokorná J, Plešek J., Grüner B., Dolečková-Marešová L., Máša M., Sedláček J., Bodem J., Krausslich H.G., Král V., Konvalinka J., Proc. Nat. Acad. Sci USA, 102 (43), 15394-15399, 2005