Organic Chemistry

Fluorinated hypervalent iodine compounds such as Togni reagents have become widely used electrophilic trifluoromethylating reagents.1 They display a unique reactivity profile and functional group compatibility. Recently, in our group we have prepared substituted tetrafluoroethylene-containing reagents and have shown their application in reactions with various nucleophiles.2 In this project, we aim to synthetize fluoroalkylated hypervalent iodine reagents bearing a functional group and investigate their utilization in tagging biological thiols. New approaches to highly selective thiol bioconjugation are of great interest to biochemists.

Key references:
1. J. Charpentier, A. Togni, et al. Chem. Rev. 2015, 115, 650.
2. V. Matousek, P. Beier, et al. Chem. Eur. J. 2016, 22, 417.