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Developmental Cardiology

Developmental Cardiology

Ischemic heart disease is the main cause of mortality worldwide. We study cardiac tolerance to injury caused by acute oxygen deprivation from the molecular level to the whole organism using animal models. Our research is focused mainly on the study of mechanisms that underlie:

 

  • high cardiac tolerance to injury early ontogeny,
  • increased cardiac tolerance induced by adaptation to chronic hypoxia and regular exercise training,
  • permanent consequences of early developmental interventions for cardiac tolerance in adulthood,
  • and altered cardiac tolerance associated with various pathological states.

 

Further we study heart development with special emphasis on the cardiac conduction system. Our current research is focused on the following projects:

  • elucidating cardiac conduction system formation with phylogenetic approaches,
  • dynamic imaging methods for cardiac conduction system,
  • and development of new methods for quantitative analysis of fibrous structures to study branching patterns of the coronary vessels and cardiac conduction system.

 

13th conference New Frontiers in Basic Cardiovascular Research

Projects

Developmental aspects of cardiac ischemic tolerance

The immature heart is highly tolerant to ischemic injury, but chronic oxygen deficit during early ontogeny may have negative consequences that persist till adulthood. We study mechanisms responsible for developmental changes of cardiac ischemic tolerance. More

Cardiac ischemic tolerance in systemic hypertension

Systemic hypertension is a major risk factor of ischemic heart disease. However, it can also stimulate mechanisms that protect the heart against acute oxygen deprivation. We study the effects of various forms of hypertension on cardiac ischemic tolerance. More

Cardioprotective mechanism of chronic hypoxia

Prolonged exposure to hypoxic environment leads to adaptation which is associated with improved cardiac tolerance to acute oxygen deprivation. We study molecular mechanisms underlying the cardioprotective effects of chronic hypoxia on various manifestations of ischemic injury. More

Publications

Steijn, R. V. - Sedmera, David - Blom, N. A. - Jongbloed, M. - Kvasilová, A. - Naňka, O. Apoptosis and epicardial contributions act as complementary factors in remodeling of the atrioventricular canal myocardium and atrioventricular conduction patterns in the embryonic chick heart . Developmental Dynamics 2018, 247(9), 1033-1042 . IF = 2.507 [ASEP] [ doi ]
Peševski, Živorad - Kvasilová, A. - Stopková, T. - Naňka, O. - Drobná Krejčí, Eliška - Buffinton, Ch. - Kočková, Radka - Eckhardt, Adam - Sedmera, David . Endocardial Fibroelastosis is Secondary to Hemodynamic Alterations in the Chick Embryonic Model of Hypoplastic Left Heart Syndrome . Developmental Dynamics 2018, roč. 247, 3, p. 509-520 . IF = 2.507 [ASEP] [ doi ]
Ošťádal, Bohuslav - Pařízek, A. - Ošťádalová, Ivana - Kolář, František . Cardiotoxicity of beta-mimetic catecholamines during ontogenetic development - possible risks of antenatal therapy . Canadian Journal of Physiology and Pharmacology 2018, roč. 96, 7, p. 639-646 . IF = 2.210 [ASEP] [ doi ]
Nedvědová, I. - Kolář, D. - Elsnicová, B. - Horníková, D. - Novotný, J. - Kalous, M. - Pravenec, Michal - Neckář, Jan - Kolář, František - Žurmanová, J.M. Mitochondrial genome modulates myocardial Akt/Glut/HK salvage pathway in spontaneously hypertensive rats adapted to chronic hypoxia . Physiological Genomics 2018, roč. 50, 7, p. 532-541 . IF = 2.782 [ASEP] [ doi ]
Neckář, Jan - Hsu, A. - Khan, M. A. H. - Gross, G. J. - Nithipatikom, K. - Cyprová, Michaela - Benák, Daniel - Hlaváčková, Markéta - Sotáková-Kašparová, Dita - Falck, J. R. - Sedmera, David - Kolář, František - Imig, J. D. Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia-inducible factor-1 alpha via downregulation of prolyl hydroxylase 3 . American Journal of Physiology-Heart and Circulatory Physiology 2018, 315(5), H1148-H1158 . IF = 3.569 [ASEP] [ doi ]

Contacts

Institute of Physiology AS CR, v.v.i.
Department of Developmental Cardiology

Vídeňská 1083
14220 Prague 4
tel. +420 241 062 559
fax. +420 241 062 125
 

kolar@biomed.cas.cz

People

     Prof. RNDr. František Kolář, CSc.
head of the department
  RNDr. Jan Neckář, Ph.D.
deputy head of the department
  Prof. MUDr. David Sedmera, DSc.
senior researcher
  Prof. MUDr. Bohuslav Ošťádal, DrSc.
senior researcher
  MUDr. Ivana Ošťádalová, CSc.
senior researcher
  Ing. František Papoušek, CSc.
senior researcher
  RNDr. Markéta Hlaváčková, Ph.D.
senior researcher
  RNDr. Marie Milerová
senior researcher
  RNDr. Petra Alánová, Ph.D.
postdoc
  Mgr. Barbora Šaňková, Ph.D.
postdoc
  RNDr. Martina Gregorovičová, Ph.D.
postdoc
    Mgr. Petra Kolesová, Ph.D.
postdoc
  Mgr. Kristýna Macháčková
PhD student
 

Mgr. Dita Sotáková

PhD student

  Mgr. Jaroslav Hrdlička
PhD student
  Ing. Michaela Cyprová
PhD student
  Mgr. Daniel Benák
PhD student
   

MUDr. Dmytro Semenovykh

PhD student

    Mgr. František Vostárek
PhD student
  MVDr. Veronika Olejníčková, Ph.D.
postdoc
  Ing. Miloslava Marková
technician
  Milana Pešková
technician
  Jarmila Svatůňková
technician
  RNDr. Kristýna Holzerová, Ph.D.
postdoc