IOCB Prague

International Summer School on Advances in Drug Discovery again in Prague

2. September 2019

On Monday, 2 September 2019, the 6^th annual Prague-Weizmann Summer School on Advances in Drug Discovery got underway at the University of Chemistry and Technology, Prague (UCT).…

Chloromethylation of nitroaromatics

23. September 2019

A novel synthetic method of chloromethylation of nitroaromatics employing vicarious nucleophilic substitution was developed and optimized in Petr Beier Group.

Another technology transfer success

14. August 2019

NTP-Transporter Technology from Tomáš Kraus et al. on the market now.

OCT

Detlef Schröder Seminar – Vítězslav Bryja

16. October 2019, IOCB Prague

NOV

Openhouse Days – Science and Technology Week 2019

11. November — 16. November 2019, IOCB…

NOV

Invited Lecture – Fraser Stoddart

20. November 2019, IOCB Prague

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Squaramate‐Modified Nucleotides and DNA for Specific Cross‐Linking with Lysine‐Containing Peptides and Proteins

Ivana Ivancová

Radek Pohl

Martin Hubálek

Michal Hocek

Angewandte Chemie International Edition 58 (38): 13345-13348 (2019).

Squaramate‐linked 2′‐deoxycytidine 5′‐O‐triphosphate was synthesized and found to be good substrate for KOD XL DNA polymerase in primer extension or PCR synthesis of modified DNA. The resulting squaramate‐linked DNA reacts with primary amines to form a stable diamide linkage. This reaction was used for bioconjugations of DNA with Cy5 and Lys‐containing peptides. Squaramate‐linked DNA formed covalent cross‐links with histone proteins. This reactive nucleotide has potential for other bioconjugations of nucleic acids with amines, peptides or proteins without need of any external reagent.

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Oxidation of the B₁₂ and CB₁₁ icosahedral anions

Jan Plutnar

Josef Michl

Handbook of Boron Science: With Applications in Organometallics, Catalysis, Materials and Medicine, Volume 3: Boron in Materials 2019 : 137-158 (2019).

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Metabolomics Based on MS in Mice with Diet-Induced Obesity and Type 2 Diabetes Mellitus: the Effect of Vildagliptin, Metformin, and Their Combination

Petra Tomášová

Martina Bugáňová

H. Pelantová

Martina Holubová

B. Šedivá

Blanka Železná

M. Haluzík

Lenka Maletínská

Jaroslav Kuneš

M. Kuzma

Applied Biochemistry and Biotechnology 188 (1): 165-184 (2019).

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