22.1. 2019, Biologie tukové tkáně

PhD project: Effects of FGF21 on adipose tissue metabolism     

Effects of FGF21 on adipose tissue metabolism

FGF21 (Fibroblast growth factor 21) is a hormone secreted mainly from the liver in response to stimuli such as fasting and ketogenic diet. Although its main physiological role is still a contested topic, FGF21 has become a promising therapeutic target for obesity and type 2 diabetes mellitus due to its powerful body weight-lowering and insulin-sensitizing effects. FGF21 exerts multiple metabolic effects on various organs including adipose tissue. The main aim of this PhD project will be detailed characterization of the effects of FGF21 on adipose tissue of experimental animals (i.e. inbred strains of mice, rodent models of obesity), namely changes in lipolysis, de novo lipogenesis and fatty acid re-esterification. Since these metabolic processes are known to be linked to preservation of healthy status of the tissue, their potential regulation by FGF21 could thus contribute to the overall beneficial metabolic action of FGF21.

Candidate’s profile (requirements):

We are seeking outstanding self-motivated candidates with master's degree in molecular biology, biochemistry, physiology, medicine or related fields, or those expecting to obtain their degree this year. Experience with in vivo models (mouse, rat) is an advantage.

Relevant publications:

Fisher FM, Maratos-Flier E. Understanding the Physiology of FGF21. Annu Rev Physiol. 2016;78:223-41.

Flachs P, Adamcova K, Zouhar P, Marques C, Janovska P, Viegas I, et al. Induction of lipogenesis in white fat during cold exposure in mice: link to lean phenotype. Int J Obes (Lond). 2017;41(6):997.

Supervisor:        Petr Zouhar, Ph.D.