The research at our departments focuses on the pathophysiology of epilepsy and epileptic seizures in adulthood and particularly in the developing brain. In our research we are utilizing modern electrophysiological, imaging, biochemical and pharmacological techniques. To elucidate the cellular and network mechanisms involved in epilepsy and to increase the translational potential of new observations we are using extensively chronic models of acquired epilepsy and also genetic models and also collaborate with leading epilepsy centres.
Our primary research topics are:
- Consequences of brain injury during early stages of the brain development
- Mechanisms responsible for seizure initiation and termination.
- Impact of seizures on the developing brain
- Development of new diagnostic techniques of epilepsy
- Cognitive and behavioural consequences of epilepsy
- The role of oxidative stress in pathogenesis of epilepsy and seizures during the development
- Impact of antiepileptic therapy of the brain development
- Age-specific mechanisms of seizure initiation and propagation
Projects
Brain-damaging insult triggers a cascade of molecular, cellular and structural changes that eventually lead to behavioral alterations and development of epilepsy. The response to the particular brain insult is highly age-dependent. Our aim is to study effects of early insults on the brain development at the molecular, cellular, and circuitry levels (maturation of receptors or ionic channel structures, vascularisation, myelination, circuitry maturation, etc.) and consequently on maturation of more complex brain functions (cognitive functions, sensorimotor skills, social and emotional behavior, brain excitability, etc.). Results of our research can be used to develop age specific pharmacological strategies for prevention of epilepsy development and disturbances of brain function.
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Systems important for brain excitability and its regulation mature for a long period of postnatal life.
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Period of perinatal and early postnatal development represents critical time for future brain functions and capabilities, as brain plasticity permits experiences to shape the immature brain.
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Oxidative stress and mitochondrial dysfunction are implicated in the pathogenesis of many neurological disorders, including epilepsy.
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Achievements
Epileptology European Award 2016 was awarded prof. Pavel Mareš.
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Publications
Svoboda, Jan - Litvinec, Andrej - Kala, David - Pošusta, Antonín - Vávrová, Lenka - Jiruška, Přemysl - Otáhal, Jakub
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Strain Differences in Intraluminal Thread Model of Middle Cerebral Artery Occlusion in Rats
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Physiological Research 2019, 68(1), 37-48
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IF = 1.701
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Mareš, Pavel - Kubová, Hana
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Changing effect of GABA B receptor antagonist CGP46381 after status epilepticus in immature rats
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Epilepsy Research 2019, 149(Jan), 17-20
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IF = 2.178
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Vodička, Martin - Ergang, Peter - Hrnčíř, Tomáš - Mikulecká, Anna - Kvapilová, Pavlína - Vagnerová, Karla - Šestáková, Blanka - Fajstová, Alena - Hermanová, Petra - Hudcovic, Tomáš - Kozáková, Hana - Pácha, Jiří
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Microbiota affects the expression of genes involved in HPA axis regulation and local metabolism of glucocorticoids in chronic psychosocial stress
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Brain Behavior and Immunity 2018, 73(Oct 2018), 615-624
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IF = 6.170
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doi
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Uttl, Libor - Petrásek, Tomáš - Sengul, Hilal - Svojanovská, Markéta - Lobellová, Veronika - Valeš, Karel - Radostová, Dominika - Tsenov, Grygoriy - Kubová, Hana - Mikulecká, Anna - Svoboda, Jan - Stuchlík, Aleš
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Chronic MK-801 Application in Adolescence and Early Adulthood: A Spatial Working Memory Deficit in Adult Long-Evans Rats But No Changes in the Hippocampal NMDA Receptor Subunits
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Frontiers in Pharmacology 2018, roč. 9, Feb 12, článku 42
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IF = 3.845
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Szczurowska, E. - Ahuja, Nikhil - Jiruška, Přemysl - Kelemen, E. - Stuchlík, Aleš
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Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine.
Progress in Neuro-Psychopharmacology & Biological Psychiatry 2018, roč. 81, Feb 2, p. 275-283
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IF = 4.315
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