List of PhD projects 2020
[Updated:
—31 December 2019: added project "Liquid nebulization in ion sources for mass spectrometry (Mass Spectrometry – Josef Cvačka)" in PHYS cluster]
CHEM cluster
- Synthesis and application of N-fluoroalkylated compounds (Petr Beier Group)
- Synthesis and transformations of fluoroalkylated heterocycles (Petr Beier Group)
- New RNA modifications for regulation of translation (Michal Hocek Group)
- Chemical or enzymatic labeling of epigenetic nucleobases in DNA (Michal Hocek Group)
- Modified nucleoside triphosphates with unnatural nucleobases for enzymatic synthesis of modified DNA (Michal Hocek Group)
- Chemical synthesis of hypermodified oligonucleotides and DNA (Michal Hocek Group)
- Nucleotides bearing polar or charged functional groups for enzymatic synthesis of modified DNA (Michal Hocek Group)
- Design and synthesis of novel photoswitches derived from bisazobenzenes (Zlatko Janeba Group)
- Synthesis of novel types of nucleotide analogues as enzyme inhibitors of nucleotide metabolism with potential antiparasitic and antibacterial activity (Zlatko Janeba Group)
- Surface-Mounted Molecular Motors (Jiří Kaleta Group)
- Molecular Machines in Supramolecular Systems (Jiří Kaleta Group)
- Development of systems for reversible electron transfer (Tomáš Slanina Group)
- Development of methods for stabilization of organic radicals (Tomáš Slanina Group)
- Nonplanar unconventional pi-electron systems (Ivo Starý Group)
- Enantioselective catalysis under the control of helical chirality (Ivo Starý Group)
- Development of chemical tools to study and manipulate biological processes in live cells (Milan Vrábel Group)
BIO cluster
- Hijacking of human host factors by viruses (Evžen Bouřa Group)
- Role, biogenesis, and biodegradation of NpnN RNA caps in prokaryotes (Hana Cahová Group)
- Chemical biology tools for drug development (Jan Konvalinka Group)
- Transient nuclear protein-protein interaction networks (Pavlína Maloy Řezáčová Group)
- Targeting hematological malignancies using fragment-based drug design (Pavlína Maloy Řezáčová Group)
- Cathepsin proteases in biomedicine (Michael Mareš Group)
- Development of machine learning algorithms for the prediction of terpene synthase activity (Tomáš Pluskal Group – starts in May 2020)
- Elucidation and engineering of the biosynthetic pathways of unique diterpenoids (Tomáš Pluskal Group – starts in May 2020)
- Metabolic engineering of novel kavalactones using yeast quiescent cells (Tomáš Pluskal Group – starts in May 2020)
- Nanoparticles for elimination of viruses spreading through air, water and bodily fluids (Virology – Jan Weber)
PHYS cluster
- Spectroscopic Studies of Protein Fibrils (Petr Bouř Group)
- Computational modeling of molecular optical activity (Petr Bouř Group)
- Lanthanide Circularly Polarized Luminescence Probes of DNA Structure (Petr Bouř Group)
- Application of metallo-DNA in nanoelectronics (Petr Bouř Group)
- Spectroscopic studies of sugar-lectin interactions (Petr Bouř Group)
- Exploring the fundamental molecular interactions modulating glycocalyx bioactivity (Pavel Jungwirth Group)
- Liquid nebulization in ion sources for mass spectrometry (Mass Spectrometry – Josef Cvačka) [added on 31 December 2019]
- NMR spectroscopy with in situ irradiation as a powerful tool to study photochemical processes (NMR Spectroscopy – David Šaman)