Design and synthesis of novel photoswitches derived from bisazobenzenes
Medicinal Chemistry of Nucleotide Analogues
Abstract
We have recently reported the synthesis of suitable substituted 5-phenylazopyrimidines (see selected references for more information). Their physicochemical properties were studied using in situ irradiation NMR spectroscopy and optical spectroscopy. The goal of the current project will be the synthesis of novel molecular photoswitches based on a combination of bisazobenzenes and pyrimidines, namely bis(pyrimidinyldiazenyl)benzenes. Their synthesis will be developed and optimized and their physicochemical properties will be evaluated.
Field of study: Organic chemistry
References :
- Procházková E., Čechová L., Kind J., Janeba Z., Thiele C.M., Dračínský M.: Photoswitchable intramolecular hydrogen bonds in 5-phenylazopyrimidines revealed by in situ irradiation NMR spectroscopy. Chem. Eur. J. 24: 492–498, 2018.
- Čechová L., Kind J., Dračínský M., Filo J., Janeba Z., Thiele C. M., Cigáň M., Procházková E.: Photoswitching behaviour of 5-phenylazopyrimidines: in situ irradiation NMR and optical spectroscopy combined with theoretical methods. J. Org. Chem. 83: 5986–5998, 2018.
Universities
PhD students must be enrolled in a partner university and will be employed by the IOCB Prague at the same time (part-time or full time), which results in a competitive salary (a scholarship from the university + a salary from the IOCB). Each university has its own process, terms, and deadlines for PhD applications, which is separate from the IOCB recruitment process. You may discuss the details with the respective PI.
How to apply
Please return to the PhD projects at IOCB Prague – Call for Applications 2020 page and follow the instructions.