Chemical or enzymatic labeling of epigenetic nucleobases in DNA
Bioorganic and Medicinal Chemistry of Nucleic Acids
Abstract
New biocompatible chemical or enzymatic reactions will be studied and developed for modification of epigenetic bases (e.g. 5hmC, 5hmU, 5fC, etc.). These reactions will be then applied in labeling, imaging or sequencing of the epigenetic nucleobases in DNA.
Field of study: Organic chemistry
Reference: Vaníková, Z.; Janoušková, M.; Kambová, M.; Krásný, L.; Hocek, M. "Switching transcription with bacterial RNA polymerase through photocaging, photorelease and phosphorylation reactions in the major groove of DNA" Chem. Sci. 2019, 10, 3937-3942.
Universities
PhD students must be enrolled in a partner university and will be employed by the IOCB Prague at the same time (part-time or full time), which results in a competitive salary (a scholarship from the university + a salary from the IOCB). Each university has its own process, terms, and deadlines for PhD applications, which is separate from the IOCB recruitment process. You may discuss the details with the respective PI.
How to apply
Please return to the PhD projects at IOCB Prague – Call for Applications 2020 page and follow the instructions.