Norbert Weiss Group

Voltage-gated-calcium channels are the primary mediators of the depolarization-induced calcium entry into neurons that initiates many cellular events. While calcium channels are of critical importance for neuronal function, it is also apparent that inappropriate expression or dysfunction gives rise to a variety of neurological disorders.

We investigate the intrinsic gating processes, as well as cell signaling pathways that control channel activity and trafficking to and from the plasma membrane, and how these regulations are compromised in disease states or by genetic mutations. Specifically, we focus on the subfamily of T-type calcium channels that are implicated in several neurological conditions, including neuropathic pain and epilepsy.