J. Med. Chem.

@JMedChem

Journal of Medicinal Chemistry publishes works that show the relationship between molecular structure and biological activity or mode of action.

pubs.acs.org/jmc
Na Twitteri od: november 2011
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  1. Pripnutý Tweet
    21. 11. 2019

    Don't forget to submit your manuscript to our upcoming Special Issue on "Artificial Intelligence in Drug Design!"

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  2. 2. 1.

    Radi and colleagues report a modulator of the cystic fibrosis transmembrane conductance regulator that simultaneously acts as a CFTR corrector and picornavirus inhibitor:

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  3. 31. 12. 2019

    Cryptic pockets, atropisomers, & covalency: The medchem story behind Amgen’s Ph II investigational KRAS(G12C) inhibitor, AMG 510:

    21 Retweetov 55 Tweetov sa páčilo
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  4. 30. 12. 2019

    San-Félix and colleagues generate potent EV71/HIV entry inhibitors that bind to the respective capsids (5-fold axis /gp120):

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  5. Retweetol používateľ
    23. 12. 2019

    A new study in shows that derivatives show improved activity against tumor-associated enzymes.

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  6. 20. 12. 2019

    to our Special Issue on "Allosteric Modulation" - have you read it yet?

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  7. 19. 12. 2019

    Novel approaches to chemically optimizing glucagon enabling biological study and therapeutic use, with relevance for other challenging therapeutic peptides:

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  8. 16. 12. 2019

    Are you interested in off-target promiscuity and strategies to mitigate? Check out the new perspectives article from AstraZeneca legacy drug discovery programs

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  9. Retweetol používateľ
    15. 12. 2019

    Today's features discovery of , a new class of intense blue by Mas Subramanian & co-workers

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  10. 15. 12. 2019

    When investigating a prodrug of CREBi 666-15, and discovered a unique drug to synergistically inhibit CREB with 666-15:

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  11. 14. 12. 2019

    Multimodal analgesia by new dual µ-opioid and σ1 receptor ligands: paving the way for effective and safer analgesics:

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  12. 13. 12. 2019

    New advances on the structure-based optimization of coumarins as hA3 adenosine receptor antagonists by and collaborators at and :

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  13. 12. 12. 2019

    MedChem excellence: lead optimization and integrative data analysis to nominate efficacious MetAP2 inhibitor M8891 as anti-cancer drug for development.

    1 reply 2 Retweety 16 Tweetov sa páčilo
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  14. 11. 12. 2019

    "Novel Propargyl-linked Bisubstrate Analogs as Tight-binding Inhibitors for Nicotinamide N-Methyltransferase”,

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  15. 10. 12. 2019

    Discovery of the ERK1/2 inhibitor AZD0364 by AstraZeneca scientists that is active in models of non-small cell lung cancer (NSCLC):

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  16. 21. 11. 2019

    Correct link to the Article:

    researchers discovered the first luteinizing hormone (LH) receptor antagonists that are suitable for in vivo administration and donate BAY-899 as chemical probe for free use in
    4 Retweety 10 Tweetov sa páčilo
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  17. 15. 11. 2019

    Starting selective and macrocyclizing led to the EGFR TKI BI-4020, which induces regressions in an Osimertinib resistant lung cancer model:

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  18. 14. 11. 2019

    Are you interested in learning how to recover antibiotic efficacy against superbugs? Then read this perspective article on beta-lactamase inhibitors by at

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  19. 12. 11. 2019

    There is still time to submit nominations for the 2020 IUPAC-Richter Prize. This award recognizes a scientist who has made a significant contribution to the field of medicinal chemistry or drug discovery. Find out more here:

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  20. 10. 11. 2019

    An investigation of the factors that dictate the preferred orientation of lexitropsins in the minor groove of DNA:

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