Application of metallo-DNA in nanoelectronics
Biomolecular Spectroscopy
Abstract
Incorporation of metals such as Hg(II) and Ag(I) into DNA leads to novel base pairs. They fit in canonical DNA duplex, and the metal array is shielded from the solvent. Moreover, the metals chained along the helical axis provide an optimal electronic pathway, suitable for enhanced charge transport. The project is aimed at theoretical modeling of physicochemical properties of various metallo-DNAs including and optimization of the functional molecules as particular nanoelectronic devices. The research is conducted in close collaboration with domestic and Japanese laboratories.
Fields of study: Analytical chemistry, chemical physics
References:
- Tanaka Y., et al. Structures, physicochemical properties, and applications of T–HgII–T, C–AgI–C, and other metallo-base-pairs” Chem. Commun., 51, (2015), pp 17343-17360.
- Dairaku T., Furuita K., Sato H., Sebera J., Nakashima K., Ono A., Sychrovsky V., Kojima C., Tanaka Y., “Hg-II/Ag-I-mediated base pairs and their NMR spectroscopic studies”, Inorg. Chim. Acta, 452, (2016), pp 34-42.
Universities
PhD students must be enrolled in a partner university and will be employed by the IOCB Prague at the same time (part-time or full time), which results in a competitive salary (a scholarship from the university + a salary from the IOCB). Each university has its own process, terms, and deadlines for PhD applications, which is separate from the IOCB recruitment process. You may discuss the details with the respective PI.
University partners
How to apply
Please return to the PhD projects at IOCB Prague – Call for Applications 2020 page and follow the instructions.