Synthesis and application of N-fluoroalkylated compounds

The recently reported synthesis of perfluoroalkyl azides and triazoles¹ opened the door to study the properties and reactivity of these compounds. In this project, the rich chemistry of (per)fluoroalkyl azides and triazoles^1-10 will be investigated and new synthetic approaches to underdeveloped N-fluoroalkyl-containing compounds such as azides, azoles, azirines, ureas, carbamates, and amides will be studied. This class of compounds is expected to find utilization in drug discovery and in the development of new materials. 

Field of study: Organic chemistry

References:

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2. S. Voltrová, M. Muselli, J. Filgas, V. Matoušek, B. Klepetářová, P. Beier Org. Biomol. Chem. 2017, 15, 4962.
3. V. Motornov, A. Markos, P. Beier Chem. Commun. 2018, 54, 3258.
4. Z. Blastik, B. Klepetářová, P. Beier Chem. Select 2018, 3, 7045.
5. S. Voltrová, I. Putovný, V. Matoušek, B. Klepetářová, P. Beier Eur. J. Org. Chem. 2018, 5087.
6. V. Motornov, P. Beier J. Org. Chem. 2018, 83, 15195.
7. A. Markos, S. Voltrová, V. Motornov, D. Tichý, B. Klepetářová, P. Beier Chem. Eur. J. 2019, 25, 7640.
8. V. Motornov, V. Košťál, A. Markos, D. Täffner, P. Beier Org. Chem. Front. 2019, 6, 3776.
9. S. Voltrová, J. Filgas, P. Slavíček, P. Beier Org. Chem. Front. DOI: 10.1039/c9qo01295h.
10. O. Bakhanovich, P. Beier Chem. Eur. J. DOI: 10.1002/chem.201903627.