Monday 4th March 2019 at 13:00 in the Turquoise Lounge (IEM)
Genetic toxicology investigates the impact of chemical, biological or physical agents on organisms. Modifications of macromolecules (DNA, lipids, proteins) are evaluated using biomarkers, measurable changes of selected parameters associated with the exposure. The exposure to chemical compounds may originate from the ambient air, water, soil, or food. Air pollution caused by vehicular traffic has many negative health effects, particularly in urban areas. Thus, it is important to monitor biological consequences of such exposure and reduce emissions production and exhaust toxicity. In this seminar we will first provide a general introduction to methods in genetic toxicology; then we will focus on air pollution associated with combustion engine emissions and the application of DNA damage detection methods.
The talks will be given by the following speakers:
RNDr. Pavel Rössner, PhD., Institute of Experimental Medicine CAS, Department of Genetic Toxicology and Nanotoxicology
Introduction to genetic toxicology: sources of air pollution, biological impacts, and their assessment
doc. Michal Vojtíšek, M.S., Ph.D., Czech Technical University, Centre of Vehicles for Sustainable Mobility
Working towards realistic assessment of health effects of combustion engine emissions reduction efforts: real-world emissions, unregulated pollutants, and exhaust toxicity
Mgr. Andrea Rössnerová, PhD., Institute of Experimental Medicine CAS, Department of Genetic Toxicology and Nanotoxicology
DNA damage detection: analysis of chromosomal aberrations
Mgr. Ing. Táňa Závodná, Institute of Experimental Medicine CAS, Department of Genetic Toxicology and Nanotoxicology
The comet assay: a method for DNA strand breaks detection
