Molecular level physiology and pathology of oxidized phospholipids

Abstract: Oxidized phospholipidis (oxPL) are now known to be involved in several pathological conditions, such as atherosclerosis, inflammation , cancer, type 2 diabetes, and Alzheimer´s disease. However, a coherent overall view of the causalities and mechanisms is lacking, mainly because of insufficient understanding of the cellular as well as molecular mechanisms. The OXPL consortium represents an integrated interdisciplinary approach of European research laboratories already active in this field, together with additional skills brought into the project by groups representing state-of-the art expertise in method and instrumentation development for the characterization of biomolecules, their interactions and localization in cells. The project will pave the way to the development of improved diagnostics, therapies and preventive measures to combat the above diseases, and will take European research to the leading edge in this emerging and important field.


Project leader: Academy of Finland