Abstract: We propose an entanglement purification scheme based on material qubits� and ancillary coherent multiphoton states. We consider a typical QED� scenario where material qubits implemented by two-level atoms fly� sequentially through a cavity and interact resonantly with a single-mode� of the radiation field. We explore the theoretical possibilities of� realizing a high-fidelity two-qubit quantum operation necessary for the� purification protocol with the help of a postselective balanced homodyne� photodetection. We demonstrate that the obtained probabilistic quantum� operation can be used as a bilateral operation in the proposed� purification scheme. It is shown that the probabilistic nature of this� quantum operation is counterbalanced in the last step of the scheme� where qubits are not discarded after inadequate qubit measurements. As� this protocol requires present-day experimental setups and generates� high fidelity entangled pairs with high repetition rates, it may offer� interesting perspectives for applications in quantum information theory.