IOCB Prague

5 June 2020

What does it mean to be a metal and how is a metal formed? These seem like textbook questions with a simple answer: Metal is characterized by free electrons which give rise to its…

Protonated organic azides fully characterized

2 June 2020

Zsófia Blastik and Petr Beier of IOCB Prague collaborated with scientists from the University of Southern California and the University of Alabama to discover the nature of…

Call for applications: Junior Group Leader position in organic synthesis

11 March 2020

IOCB Prague invites applications for a Junior Group Leader position in synthetic organic chemistry with a strong emphasis on synthetic approaches to complex target molecules at…

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Protonation of CH<sub>3</sub>N<sub>3</sub> and CF<sub>3</sub>N<sub>3</sub> in Superacids: Isolation and Structural Characterization of Long‐Lived Methyl‐ and Trifluoromethylamino Diazonium Ions

Protonation of CH₃N₃ and CF₃N₃ in Superacids: Isolation and Structural Characterization of Long‐Lived Methyl‐ and Trifluoromethylamino Diazonium Ions

S. G. Prakash

T. Saal

Z. Blastik

R. Haiges

A. Nirmalchandar

A. F. Baxter

K. O. Christe

M. Vasiliu

D. A. Dixon

P. Beier

Angewandte Chemie International Edition 2020 : Early View (2020).

The methylamino diazonium cations [CH₃N(H)N₂]⁺ and [CF₃N(H)N₂]⁺ were prepared as their low‐temperature stable [AsF₆]^‐ salts by protonation of azidomethane and azidotrifluoromethane in superacidic systems. They were characterized by NMR and Raman spectroscopy. Unequivocal proof of the protonation site was obtained by the crystal structures of both salts, confirming the formation of alkylamino diazonium ions. The Lewis acid‐base adducts CH₃N₃·AsF₅ and CF₃N₃·AsF₅ were also prepared and characterized by low‐temperature NMR and Raman spectroscopy, and, in case of CH₃N₃·AsF₅, by X‐ray structure determination. Electronic structure calculations were performed to provide additional insights. Attempted electrophilic amination of aromatics such as benzene and toluene with methyl ‐and trifluoromethyl‐amino diazonium ions were unsuccessful.

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Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX

J. Štěpánková

M. Kugler

J. Holub

V. Šícha

V. Das

J. Nekvinda

S. E. Anwar

M. Havránek

K. Pospíšilová

M. Fábry

V. Král

M. Medvedíková

S. Matějková

B. Lišková

S. Gurská

P. Džubák

J. Brynda

M. Hajdúch

B. Grüner

P. Řezáčová

European Journal of Medicinal Chemistry 2020 : Early View (2020).

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A Systematic Study of Coumarin‐Tetrazine Light‐Up Probes for Bioorthogonal Fluorescence Imaging

J. Galeta R. Dzijak J. Obořil M. Dračínský M. Vrábel

Chemistry - A European Journal 2020 : Early View (2020).

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Helquats as Promoters of the Povarov Reaction: Synthesis of 1,2,3,4‐Tetrahydroquinoline Scaffolds Catalyzed by Helicene‐Viologen Hybrids

P. E. R. Gutierrez T. Amatov P. Švec

I. Císařová

D. Šaman R. Pohl F. Teplý L. Pospíšil

ChemPlusChem 2020 : Early View (2020).

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