Intranet English

Vývojová epileptologie

Vývojová epileptologie

Výzkum našeho oddělení je zaměřen na různé patofyziologické aspekty epilepsie a epileptických záchvatů, především v období vývoje mozku. Ke studiu využíváme moderních technik (elektrofyziologie, zobrazovacích metod, biochemie, farmakologie, morfologie) a výzkum provádíme na buněčné úrovni, na úrovni tkání, ale také in vivo v chronických a genetických modelech epilepsie.

 

Zabýváme se výzkumem v těchto oblastech:

  • Důsledky časného poškození mozku a prevence vzniku epilepsie
  • Studium mechanizmů odpovědných za vznik a ukončení epileptických záchvatů
  • Odlišnosti vzniku epileptických záchvatů v nezralém mozku.
  • Vývoj nových diagnostických metod v epileptologii
  • Studium nových farmakologických postupů léčby epilepsie a neuroprotekce
  • Studium kognitivních and behavioráních následků epilepsie
  • Úloha oxidativního stresu v patogenezi epilepsie a záchvatů v nezralém mozku
  • Důsledky podávání neurofarmak a psychofarmak pro další vývoj mozku
  • Věkově specifické mechanismy vziku a šíření epileptické aktivity 

Aktuální projekty

Důsledky časného poškození mozku a prevence vzniku epilepsie a funkčního poškození.

Poškození mozku v časných vývojových stadiích vede k celé řadě funkčních i neuropatologických změn, jejichž charakter závisí nejen na mechanismu, vedoucímu k poškození, ale i na věku, kdy k poškození došlo. Nervová tkáň reaguje na inzult spuštěním celé řady molekulárních, buněčných i strukturálních změn, které na jedné straně vedou k částečnému vyrovnání vzniklých deficitů, na druhé straně však mohou být zodpovědné za vznik epilepsie. Spolu s epilepsií může dojít i ke vzniku poruch chování, poškození kognitivních funkcí či zvýšení rizika vzniku psychiatrických onemocnění. Cílem našeho výzkumu je  sledovat věkově specifický charakter těchto funkčních i neuropatologických změn a tyto poznatky dále využít pro hledání nových farmakologických postupů, které by mohly vzniku epilepsie a psychiatrických problémů zabránit.  Více

Úspěchy

Publikace

Vodička, Martin - Ergang, Peter - Hrnčíř, Tomáš - Mikulecká, Anna - Kvapilová, Pavlína - Vagnerová, Karla - Šestáková, Blanka - Fajstová, Alena - Hermanová, Petra - Hudcovic, Tomáš - Kozáková, Hana - Pácha, Jiří . Microbiota affects the expression of genes involved in HPA axis regulation and local metabolism of glucocorticoids in chronic psychosocial stress . Brain Behavior and Immunity 2018, 73(Oct 2018), 615-624 . IF = 6.306 [ASEP] [ doi ]
Uttl, Libor - Petrásek, Tomáš - Sengul, Hilal - Svojanovská, Markéta - Lobellová, Veronika - Valeš, Karel - Radostová, Dominika - Tsenov, Grygoriy - Kubová, Hana - Mikulecká, Anna - Svoboda, Jan - Stuchlík, Aleš . Chronic MK-801 Application in Adolescence and Early Adulthood: A Spatial Working Memory Deficit in Adult Long-Evans Rats But No Changes in the Hippocampal NMDA Receptor Subunits . Frontiers in Pharmacology 2018, roč. 9, Feb 12, článku 42 . IF = 3.831 [ASEP] [ doi ]
Szczurowska, E. - Ahuja, Nikhil - Jiruška, Přemysl - Kelemen, E. - Stuchlík, Aleš . Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2018, roč. 81, Feb 2, p. 275-283 . IF = 4.185 [ASEP] [ doi ]
Mareš, Pavel - Bernášková, Klára - Kubová, Hana . Ontogenetic Development of Sensitivity of the Cerebral Cortex to an Antagonist of GABA(A) Receptor Bicuculline . Physiological Research 2018, roč. 67, 1, p. 149-153 . IF = 1.324 [ASEP]
Mareš, Pavel . Participation of GABA(B) receptors in cortical postictal excitability in immature rats . European Journal of Pharmacology 2018, roč. 818, Jan 5, p. 26-29 . IF = 3.040 [ASEP] [ doi ]
Kubová, Hana - Folbergrová, Jaroslava - Rejchrtová, Jana - Tsenov, Grygoriy - Pařízková, Martina - Burchfiel, J. - Mikulecká, Anna - Mareš, Pavel . The Free Radical Scavenger N-Tert-Butyl-alpha-Phenylnitrone (PBN) Administered to Immature Rats During Status Epilepticus Alters Neurogenesis and Has Variable Effects, Both Beneficial and Detrimental, on Long-Term Outcomes . Frontiers in Cellular Neuroscience 2018, roč. 12, Aug 28, článku 266 . IF = 4.300 [ASEP] [ doi ]
Kubová, Hana - Bendová, Z. - Moravcová, S. - Pačesová, D. - Rocha, L. L. - Mareš, Pavel . Neonatal Clonazepam Administration Induces Long-Lasting Changes in Glutamate Receptors . Frontiers in Molecular Neuroscience 2018, 11(Oct 11)), 382 . IF = 3.902 [ASEP] [ doi ]
Kovács, R. - Gerevich, Z. - Friedman, A. - Otáhal, Jakub - Prager, O. - Gabriel, S. - Berndt, N. Bioenergetic Mechanisms of Seizure Control . Frontiers in Cellular Neuroscience 2018, 12(Oct 8)), 335 . IF = 4.300 [ASEP] [ doi ]
Janča, R. - Kršek, P. - Ježdík, P. - Čmejla, R. - Tomášek, M. - Komárek, V. - Marusič, P. - Jiruška, Přemysl . The Sub-Regional Functional Organization of Neocortical Irritative Epileptic Networks in Pediatric Epilepsy . Frontiers in Neurology 2018, roč. 9, Mar 23, článku 184 . IF = 3.508 [ASEP] [ doi ]
Chouzouris, T. - Omelchenko, I. - Zakharova, A. - Hlinka, Jaroslav - Jiruška, Přemysl - Schöll, E. Chimera States in Brain Networks: Empirical Neural vs. Modular Fractal Connectivity . Chaos 2018, roč. 28, 4, článku 045112 . IF = 2.415 [ASEP] [ doi ]
Chang, W.C. - Kudláček, Jan - Hlinka, Jaroslav - Chvojka, Jan - Hadrava, Michal - Kumpošt, Vojtěch - Powell, A. D. - Janča, R. - Maturana, M. I. - Karoly, P. J. - Freestone, D. R. - Cook, M. J. - Paluš, Milan - Otáhal, Jakub - Jefferys, J. G. R. - Jiruška, Přemysl . Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations . Nature Neuroscience 2018, 21(12), 1742-1752 . IF = 19.912 [ASEP] [ doi ]
Holubová, A. - Mikulecká, Anna - Pometlová, M. - Nohejlová, K. - Šlamberová, R. Long-term early life adverse experience impairs responsiveness to exteroceptive stimuli in adult rats . Behavioural Processes 2018, roč. 149, Apr, p. 59-64 . IF = 1.555 [ASEP] [ doi ]
Folbergrová, Jaroslava - Ješina, Pavel - Kubová, Hana - Otáhal, Jakub . Effect of Resveratrol on Oxidative Stress and Mitochondrial Dysfunction in Immature Brain during Epileptogenesis . Molecular Neurobiology 2018, roč. 55, 9, p. 7512-7522 . IF = 5.076 [ASEP] [ doi ]
Ergang, Peter - Mikulecká, Anna - Vodička, Martin - Vagnerová, Karla - Mikšík, Ivan - Pácha, Jiří . Social defeat stimulates local glucocorticoid regeneration in lymphoid organs . Endocrine Connections 2018, 7(12), 1389-1396 . IF = 3.041 [ASEP] [ doi ]
Abbasova, Kenul - Kubová, Hana - Mareš, Pavel . Does status epilepticus modify the effect of ifenprodil on cortical epileptic afterdischarges in immature rats? . Pharmacological Reports 2018, roč. 70, 1, p. 126-132 . IF = 2.787 [ASEP] [ doi ]
Vondráková, Kateřina - Uttl, Libor - Kubová, Hana - Tsenov, Grygoriy - Kačer, P. Mikrodialýza a hmotnostní spektrometrie jako klíč k monitorování metabolitů v nezralém mozku . Chemické listy. 2017, roč. 111, 1, p. 66-69 . IF = 0.26 [ASEP]
Tsenov, Grygoriy - Kubová, Hana - Mareš, Pavel . Which component of treatment is important for changes of cortical epileptic afterdischarges after status epilepticus in immature rats? . Neuroscience Letters. 2017, roč. 644, Mar 22, p. 1-4 . IF = 2.159 [ASEP] [ doi ]
Raimondo, J. V. - Heinemann, U. - de Curtis, M. - Goodkin, H. P. - Dulla, Ch. G. - Janigro, D. - Ikeda, A. - Lin, Ch.-Ch. K. - Jiruška, Přemysl - Galanopoulou, A. S. - Bernard, Ch. Methodological standards for in vitro models of epilepsy and epileptic seizures. A TASK1-WG4 report of the AES/ILAE Translational Task Force of the ILAE . Epilepsia.. 2017, roč. 58, Suppl.4, p. 40-52 . IF = 5.067 [ASEP] [ doi ]
Moyer, J. T. - Gnatkovsky, V. - Ono, T. - Otáhal, Jakub - Wagenaar, J. - Stacey, W. C. - Noebels, J. - Ikeda, A. - Staley, K. - de Curtis, M. - Litt, B. - Galanopoulou, A. S. Standards for data acquisition and software-based analysis of in vivo electroencephalography recordings from animals. A TASK1-WG5 report of the AES/ILAE Translational Task Force of the ILAE . Epilepsia.. 2017, roč. 58, Suppl.4, p. 53-67 . IF = 5.067 [ASEP] [ doi ]
Kudláček, Jan - Chvojka, Jan - Pošusta, Antonín - Kováčová, Ľubica - Hong, S.B. - Weiss, S. - Volná, K. - Marusič, P. - Otáhal, Jakub - Jiruška, Přemysl . Lacosamide and Levetiracetam Have No Effect on Sharp-Wave Ripple Rate . Frontiers in Neurology.. 2017, roč. 8, Dec 21, článku 687 . IF = 3.508 [ASEP] [ doi ]
Jiruška, Přemysl - Alvarado-Rojas, C. - Schevon, C.A. - Staba, R. - Stacey, W. - Wendling, F. - Avoli, M. Update on the mechanisms and roles of high-frequency oscillations in seizures and epileptic disorders . Epilepsia. 2017, roč. 58, 8, p. 1330-1339 . IF = 5.067 [ASEP] [ doi ]
Hejčl, Aleš - Vondráková, Kateřina - Kelbich, P. - Sameš, M. - Tsenov, Grygoriy - Kačer, P. Model cerebrálních vazospasmů a metabolomické mapování . Chemické listy. 2017, roč. 111, 1, p. 56-61 . IF = 0.26 [ASEP]
Kasal, Alexander - Buděšínský, Miloš - Mareš, Pavel - Krištofíková, Z. - Leitao, A. J. - Sá e Melo, M. L. - Silva, M. M. C. Neurosteroids: Can a 2alpha,3alpha-epoxy ring make up for the 3alpha-hydroxyl group? . Steroids. 2016, roč. 105, Jan, p. 12-18 . IF = 2.282 [ASEP] [ doi ]
Šlamberová, R. - Mikulecká, Anna - Macúchová, E. - Hrebíčková, I. - Ševčíková, M. - Nohejlová, K. - Pometlová, M. Morphine Decreases Social Interaction of Adult Male Rats, While THC Does Not Affect It . Physiological Research. 2016, roč. 65, Suppl.5, S547-S555 . IF = 1.461 [ASEP]
Riljak, V. - Kraf, J. - Daryanani, A. - Jiruška, Přemysl - Otáhal, Jakub . Pathophysiology of perinatal hypoxic-ischemic encephalopathy – biomarkers, animal models and treatment perspectives . Physiological Research. 2016, roč. 65, Suppl.5, S533-S545 . IF = 1.461 [ASEP]
Tykalová, T. - Pospíšilová, M. - Čmejla, R. - Jeřábek, J. - Mareš, Pavel - Rusz, J. Speech changes after coordinative training in patients with cerebellar ataxia: a pilot study . Neurological Sciences. 2016, roč. 37, 2, p. 293-296 . IF = 1.749 [ASEP] [ doi ]
Morris, G. - Jiruška, Přemysl - Jefferys, J. G. R. - Powell, A. D. A New Approach of Modified Submerged Patch Clamp Recording Reveals Interneuronal Dynamics during Epileptiform Oscillations . Frontiers in Neuroscience. 2016, roč. 10, Nov 9, článku 519 . IF = 3.566 [ASEP] [ doi ]
Folbergrová, Jaroslava - Ješina, Pavel - Kubová, Hana - Druga, Rastislav - Otáhal, Jakub . Status Epilepticus in Immature Rats Is Associated with Oxidative Stress and Mitochondrial Dysfunction . Frontiers in Cellular Neuroscience. 2016, roč. 10, May 26, p. 136 . IF = 4.555 [ASEP] [ doi ]
Szczurowska, Ewa - Ergang, Peter - Kubová, Hana - Druga, Rastislav - Salaj, M. - Mareš, Pavel . Influence of early life status epilepticus on the developmental expression profile of the GluA2 subunit of AMPA receptors . Experimental Neurology. 2016, roč. 283, Part A, p. 97-109 . IF = 4.706 [ASEP] [ doi ]
Mareš, Pavel - Kubová, Hana . Does status epilepticus induced at early postnatal period change excitability after cortical epileptic afterdischarges? . Epilepsia. 2016, roč. 57, 8, E183-E186 . IF = 5.295 [ASEP] [ doi ]
Fábera, Petr - Krijtová, H. - Tomášek, M. - Krýsl, D. - Zámečník, J. - Mohapl, M. - Jiruška, Přemysl - Marusič, P. Familial temporal lobe epilepsy due to focal cortical dysplasia type IIIa . Seizure-European Journal of Epilepsy. 2015, Vol. 31, -, p. 120-123 . IF = 2.109 [ASEP] [ doi ]
Suchomelová, L. - Lopes-Meraz, M. L. - Niquet, J. - Kubová, Hana - Wasterlain, C. G. Hyperthermia aggravates status epilepticus-induced epileptogenesis and neuronal loss in immature rats . Neuroscience. 2015, Vol. 305, Oct 1, p. 209-224 . IF = 3.231 [ASEP] [ doi ]
Mareš, Pavel - Kubová, Hana . GABA(B), not GABA(A) receptors play a role in cortical postictal refractoriness . Neuropharmacology. 2015, Vol. 88, Jan 2015, p. 99-102 . IF = 4.936 [ASEP] [ doi ]
Pošusta, Antonín - Sporka, A. J. - Poláček, O. - Rudolf, Š. - Otáhal, Jakub . Control of word processing environment using myoelectric signals . Journal on Multimodal User Interfaces. 2015, Vol. 9, 4, p. 299-311 . IF = 1.017 [ASEP] [ doi ]
Druga, Rastislav - Salaj, M. - Barinka, F. - Edelstein, L. - Kubová, Hana . Calretinin immunoreactivity in the claustrum of the rat . Frontiers in Neuroanatomy. 2015, Vol. 8, Jan 20, p. 160 . IF = 3.26 [ASEP] [ doi ]
Tsenov, Grygoriy - Vondráková, Kateřina - Otáhal, Jakub - Burchfiel, J. - Kubová, Hana . Activation of either the ETA or the ETB receptors is involved in the development of electrographic seizures following intrahippocampal infusion of the endothelin-1 in immature rats . Experimental Neurology. 2015, Vol. 265, Mar 2015, p. 40-47 . IF = 4.657 [ASEP] [ doi ]
Szczurowska, Ewa - Mareš, Pavel . An antagonist of calcium permeable AMPA receptors, IEM1460: Anticonvulsant action in immature rats? . Epilepsy Research. 2015, Vol. 109, Jan 2015, p. 106-113 . IF = 2.237 [ASEP] [ doi ]
Rektor, I. - Schachter, S.C. - Arya, R. - Arzy, S. - Braakman, H. - Brodie, M.J. - Brugger, P. - Chang, B. S. - Guekht, A. - Hermann, B. - Hesdorffer, D. C. - Jones-Gotman, M. - Kanner, A.M. - Garcia-Larrea, L. - Mareš, Pavel - Mula, M. - Neufeld, M. - Risse, G. L. - Ryvlin, P. - Seeck, M. - Tomson, T. - Korczyn, A.D. Third International Congress on Epilepsy, Brain, and Mind: Part 2 . Epilepsy and Behavior. 2015, Vol. 50, Sep 2015, p. 138-159 . IF = 2.332 [ASEP] [ doi ]
Mareš, Pavel - Kubová, Hana . Developmental patterns of postictal refractoriness and potentiation akin to cortical stimulation . Epilepsia. 2015, Vol. 56, 1, e10-e14 . IF = 4.706 [ASEP] [ doi ]
Janča, R. - Ježdík, P. - Čmejla, R. - Tomášek, M. - Worrell, G. A. - Stead, M. - Wagenaar, J. - Jefferys, J. G. R. - Kršek, P. - Komárek, V. - Jiruška, Přemysl - Marusič, P. Detection of Interictal Epileptiform Discharges Using Signal Envelope Distribution Modelling: Application to Epileptic and Non-Epileptic Intracranial Recordings . Brain Topography. 2015, Vol. 28, 1, p. 172-183 . IF = 3.727 [ASEP] [ doi ]
Ferecskó, A. S. - Jiruška, Přemysl - Foss, L. - Powell, A. D. - Chang, W.C. - Sik, A. - Jefferys, J. G. R. Structural and functional substrates of tetanus toxin in an animal model of temporal lobe epilepsy . Brain Structure and Function. 2015, Vol. 220, 2, p. 1013-1029 . IF = 5.811 [ASEP] [ doi ]
Salaj, M. - Druga, Rastislav - Cerman, J. - Kubová, Hana - Barinka, F. Calretinin and parvalbumin immunoreactive interneurons in the retrosplenial cortex of the rat brain: Qualitative and quantitative analyses . Brain Research. 2015, Vol. 1627, Nov 19, p. 201-215 . IF = 2.561 [ASEP] [ doi ]
Szczurowska, Ewa - Mareš, Pavel . Different action of a specific NR2B/NMDA antagonist Ro 25-6981 on cortical evoked potentials and epileptic afterdischarges in immature rats . Brain Research Bulletin. 2015, Vol. 111, Jan 2015, p. 1-8 . IF = 2.572 [ASEP] [ doi ]
Šlamberová, R. - Mikulecká, Anna - Macúchová, E. - Hrebíčková, I. - Ševčíková, M. - Nohejlová, K. - Pometlová, M. Effects of psychostimulants on social interaction in adult male rats . Behavioural Pharmacology. 2015, Vol. 26, 8, p. 776-785 . IF = 2 [ASEP] [ doi ]
Zavala-Tecuapetla, Cecília - Kubová, Hana - Otáhal, Jakub - Tsenov, Grygoriy - Mareš, Pavel . Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP . Pharmacological Reports. 2014, roč. 66, 5, p. 927-930. ISSN 1734-1140. IF = 1.928 [ASEP] [ doi ]
Vodička, Martin - Ergang, Peter - Mikulecká, Anna - Řeháková, Lenka - Klusoňová, Petra - Makal, J. - Soták, Matúš - Musílková, Jana - Zach, P. - Pácha, Jiří . Regulation of 11 beta-Hydroxysteroid Dehydrogenase Type 1 and 7 alpha-Hydroxylase CYP7B1 during Social Stress . PLoS ONE 2014, roč. 9, 2, e89421. ISSN 1932-6203. IF = 3.234 [ASEP] [ doi ]
Tchekalarova, J.D. - Kubová, Hana - Mareš, Pavel . Early caffeine exposure: Transient and long-term consequences on brain excitability . Brain Research Bulletin 2014, roč. 104, -, p. 27-35. ISSN 0361-9230. IF = 2.718 [ASEP] [ doi ]
Powell, A. D. - Saintot, P.P. - Gill, K. K. - Bharathan, A. - Buck, S.C. - Morris, G. - Jiruška, Přemysl - Jefferys, J. G. R. Reduced Gamma Oscillations in a Mouse Model of Intellectual Disability: A Role for Impaired Repetitive Neurotransmission? . PLoS ONE 2014, roč. 9, 5, e95871. ISSN 1932-6203. IF = 3.234 [ASEP] [ doi ]
Otáhal, Jakub - Folbergrová, Jaroslava - Kovacs, R. - Kunz, W.S. - Maggio, N. Epileptic Focus and Alteration of Metabolism . International Review of Neurobiology 2014, roč. 114, 2014, p. 209-243. ISSN 0074-7742. IF = 1.921 [ASEP] [ doi ]
Nieto-Rostro, M. - Sandhu, G. - Bauer, C. S. - Jiruška, Přemysl - Jefferys, J. G. R. - Dolphin, A. C. Altered expression of the voltage-gated calcium channel subunit alpha(2)delta-1: A comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain . Neuroscience. 2014, roč. 283, dec, p. 124-137. ISSN 0306-4522. IF = 3.357 [ASEP] [ doi ]
Mikulecká, Anna - Šubrt, Martin - Stuchlík, Aleš - Kubová, Hana . Consequences of early postnatal benzodiazepines exposure in rats. I. Cognitive-like behavior . Frontiers in Behavioral Neuroscience 2014, roč. 8, -, p. 101. ISSN 1662-5153. IF = 3.27 [ASEP] [ doi ]
Mikulecká, Anna - Šubrt, Martin - Pařízková, Martina - Mareš, Pavel - Kubová, Hana . Consequences of early postnatal benzodiazepines exposure in rats. II. Social behavior . Frontiers in Behavioral Neuroscience 2014, roč. 8, may 8, p. 169. ISSN 1662-5153. IF = 3.27 [ASEP] [ doi ]
Mareš, Pavel - Tichá, Kateřina - Mikulecká, Anna . Anticonvulsant and behavioral effects of muscimol in immature rats . Brain Research 2014, roč. 1582, sep 25, p. 227-236. ISSN 0006-8993. IF = 2.843 [ASEP] [ doi ]
Mareš, Pavel . Age and activation determines the anticonvulsant effect of ifenprodil in rats . Naunyn-Schmiedeberg's Archives of Pharmacology 2014, roč. 387, 8, p. 753-761. ISSN 0028-1298. IF = 2.471 [ASEP] [ doi ]
Mareš, Pavel . A1 not A2A adenosine receptors play a role in cortical epileptic afterdischarges in immature rats . Journal of Neural Transmission. 2014, roč. 121, 11, p. 1329-1336. ISSN 0300-9564 . IF = 2.402 [ASEP] [ doi ]
Kletečková, Lenka - Tsenov, Grygoriy - Kubová, Hana - Stuchlík, Aleš - Valeš, Karel . Neuroprotective effect of the 3 alpha 5 beta-pregnanolone glutamate treatment in the model of focal cerebral ischemia in immature rats . Neuroscience Letters 2014, roč. 564, apr 3, p. 11-15. ISSN 0304-3940. IF = 2.03 [ASEP] [ doi ]
Jiruška, Přemysl - de Curtis, M. - Jefferys, J. G. R. Modern Concepts of Focal Epileptic Networks . International Review of Neurobiology 2014, roč. 114, 2014, p. 1-7. ISSN 0074-7742. IF = 1.921 [ASEP] [ doi ]
Cho, J.R. - Koo, D.L. - Joo, E.Y. - Seo, D.W. - Hong, S.-Ch. - Jiruška, Přemysl - Hong, S.B. Resection of individually identified high-rate high-frequency oscillations region is associated with favorable outcome in neocortical epilepsy . Epilepsia 2014, roč. 55, 11, p. 1872-1883. ISSN 0013-9580. IF = 4.571 [ASEP] [ doi ]
Fábera, Pavel - Mareš, Pavel . Effect of GABAB receptor agonist SKF97541 on cortical and hippocampal epileptic afterdischarges . Physiological Research. 2014, roč. 63, 4, p. 529-534 . IF = 1.293 [ASEP]
Brožíčková, Carole - Mikulecká, Anna - Otáhal, Jakub . Effect of 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, on behavioral and physiological parameters . Physiological Research. 2014, roč. 63, 5, p. 637-648 . IF = 1.293 [ASEP]
Blauwblomme, T. - Jiruška, Přemysl - Huberfeld, G. Mechanisms of Ictogenesis . International Review of Neurobiology 2014, roč. 114, 2014, p. 155-185. ISSN 0074-7742. IF = 1.921 [ASEP] [ doi ]
Tchekalarova, Jana - Kubová, Hana - Mareš, Pavel . Effects of caffeine on cortical epileptic afterdischarges in adult rats are modulated by postnatal treatment . Acta Neurologica Belgica, 2013, Vol. 113, 4, p. 493-500 . IF = 0.466 [ASEP] [ doi ]
Tchekalarova, Jana - Kubová, Hana - Mareš, Pavel . Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood . Pharmacological Reports, 2013, Vol. 65, 4, p. 847-853 . IF = 1.965 [ASEP]
Szczurowska, Ewa - Mareš, Pavel . NMDA and AMPA receptors: development and status epilepticus . Physiological Research, 2013, Vol. 62, Suppl.1, S21-S38 . IF = 1.531 [ASEP]
Ostrý, S. - Belšan, T. - Otáhal, Jakub - Beneš, V. - Netuka, D. Is Intraoperative Diffusion tensor Imaging at 3.0T Comparable to Subcortical Corticospinal tract Mapping? . Neurosurgery, 2013, Vol. 73, 5, p. 797-807 . IF = 2.532 [ASEP]
Mareš, Pavel - Kubová, Hana - Hen, N. - Yagen, B. - Bialer, M. Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats . Epilepsy Research, 2013, Vol. 106, 1-2, p. 64-73 . IF = 2.241 [ASEP] [ doi ]
Mareš, Pavel - Tichá, Kateřina - Mikulecká, Anna . Anticonvulsant and behavioral effects of GABA(B) receptor positive modulator CGP7930 in immature rats . Epilepsy and Behavior, 2013, Vol. 28, 1, p. 113-120 . IF = 1.844 [ASEP] [ doi ]
Mareš, Pavel . Proconvulsant Action of Two GABA(B) Receptor Antagonists Is Age-Dependent . Physiological Research, 2013, Vol. 62, Suppl.1, S109-S114 . IF = 1.531 [ASEP]
Kubová, Hana - Mareš, Pavel . Are morphologic and functional consequences of status epilepticus in infant rats progressive? . Neuroscience, 2013, Vol. 235, APR 3, p. 232-249 . IF = 3.122 [ASEP] [ doi ]
Korczyn, A.D. - Schachter, S.C. - Brodie, M.J. - Dalal, S.S. - Engel Jr., J. - Guekht, A. - Hecimovic, H. - Jerbi, K. - Kanner, A.M. - Landmark, C.J. - Mareš, Pavel - Marusič, P. - Meletti, S. - Mula, M. - Patsalos, P. N. - Reuber, M. - Ryvlin, P. - Štill . Epilepsy, cognition, and neuropsychiatry (Epilepsy, Brain, and Mind, part 2) . Epilepsy and Behavior, 2013, Vol. 28, 2, p. 283-302 . IF = 1.844 [ASEP] [ doi ]
Jiruška, Přemysl - de Curtis, M. - Jefferys, J. G. R. - Schevon, C.A. - Schiff, S.J. - Schindler, K. Synchronization and desynchronization in epilepsy: controversies and hypotheses . Journal of Physiology, 2013, Vol. 591, 4, p. 787-797 . IF = 4.380 [ASEP] [ doi ]
Jiruška, Přemysl - Shtaya, A.B.Y. - Bodansky, D.M.S. - Chang, W.C. - Gray, W.P. - Jefferys, J. G. R. Dentate gyrus progenitor cell proliferation after the onset of spontaneous seizures in the tetanus toxin model of temporal lobe epilepsy . Neurobiology of Disease, 2013, Vol. 54, Jun 2013, p. 492-498 . IF = 5.624 [ASEP] [ doi ]
Folbergrová, Jaroslava - Ješina, Pavel - Nůsková, Hana - Houštěk, Josef . Antioxidant enzymes in cerebral cortex of immature rats following experimentally-induced seizures: upregulation of mitochondrial MnSOD (SOD2) . International Journal of Developmental Neuroscience, 2013, Vol. 31, 2, p. 123-130 . IF = 2.692 [ASEP] [ doi ]
Folbergrová, Jaroslava . Oxidative stress in immature brain following experimentally-induced seizures . Physiological Research, 2013, Vol. 62, Suppl.1, S39-S48 . IF = 1.531 [ASEP]
Brožíčková, Carole - Otáhal, Jakub . Effect of an inhibitor of neuronal nitric oxide synthase 7-nitroindazole on cerebral hemodynamic response and brain excitability in urethane-anesthetized rats . Physiological Research, 2013, Vol. 62, Suppl.1, S57-S66 . IF = 1.531 [ASEP]
Brima, Tufikameni - Otáhal, Jakub - Mareš, Pavel . Increased susceptibility to pentetrazol-induced seizures in developing rats after cortical photothrombotic ischemic stroke at P7 . Brain Research, 2013, Vol. 1507, APR 24, p. 146-153 . IF = 2.879 [ASEP] [ doi ]
Brima, Tufikameni - Mikulecká, Anna - Otáhal, Jakub . Impacts of perinatal induced photothrombotic stroke on sensorimotor performance in adult rats . Physiological Research, 2013, Vol. 62, 1, p. 85-94 . IF = 1.531 [ASEP]
Zijlmans, M. - Jiruška, Přemysl - Zelmann, R. - Leijten, F. S. S. - Jefferys, J. G. R. - Gotman, J. High-frequency oscillations as a new biomarker in epilepsy . Annals of Neurology, 2012, Vol. 71, 2, p. 169-178 . IF = 11.193 [ASEP] [ doi ]
Szczurowska, Ewa - Mareš, Pavel . Positive allosteric modulator of mGluR4 PHCCC exhibits proconvulsant action in three models of epileptic seizures in immature rats . Physiological Research, 2012, Vol. 61, 6, p. 619-628 . IF = 1.531 [ASEP]
Powell, A. D. - Gill, K. K. - Saintot, P.P. - Jiruška, Přemysl - Chelly, J. - Billuart, P. - Jefferys, J. G. R. Rapid reversal of impaired inhibitory and excitatory transmission but not spine dysgenesis in a mouse model of mental retardation . Journal of Physiology, 2012, Vol. 590, 4, p. 763-775 . IF = 4.380 [ASEP] [ doi ]
Mareš, Pavel . Models of epileptic seizures in immature rats . Physiological Research, 2012, Vol. 61, Suppl.1, S103-S108 . IF = 1.531 [ASEP]
Mareš, Pavel . Anticonvulsant action of GABA(B) receptor positive modulator CGP7930 in immature rats . Epilepsy Research, 2012, Vol. 100, 1-2, p. 49-54 . IF = 2.241 [ASEP] [ doi ]
Mareš, Pavel - Bernášková, Klára - Kubová, Hana . An antagonist of GABA-B receptors potentiates activity of cortical epileptic foci . Physiological Research, 2012, Vol. 61, 3, p. 325-329 . IF = 1.531 [ASEP]
Kubová, Hana - Mareš, Pavel . Partial agonist of benzodiazepine receptors Ro 19-2088 elicits withdrawal symptoms after short-term administration in immature rats . Physiological Research, 2012, Vol. 61, 3, p. 319-323 . IF = 1.531 [ASEP]
Konopková, Renata - Világi, I. - Borbély, S. - Kubová, Hana - Otáhal, Jakub . Effect of endothelin-1 on the excitability of rat cortical and hippocampal slices in vitro . Physiological Research, 2012, Vol. 61, 2, p. 215-219 . IF = 1.531 [ASEP]
Beamer, E. - Otáhal, Jakub - Sills, G.J. - Thippeswamy, T. N-w-Propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses . European Journal of Neuroscience, 2012, Vol. 36, 9, p. 3194-3203 . IF = 3.753 [ASEP] [ doi ]
Barinka, F. - Salaj, M. - Rybář, J. - Krajčovičová, Eva - Kubová, Hana - Druga, Rastislav . Calretinin, parvalbumin and calbindin immunoreactive interneurons in perirhinal cortex and temporal area Te3V of the rat brain: Qualitative and quantitative analyses . Brain Research, 2012, Vol. 1436, FEB 3, p. 68-80 . IF = 2.879 [ASEP] [ doi ]
Folbergrová, Jaroslava - Kunz, W.S. Mitochondrial dysfunction in epilepsy . Mitochondrion, 2012, Vol. 12, 1, p. 35-40 . IF = 4.025 [ASEP] [ doi ]
Folbergrová, Jaroslava - Otáhal, Jakub - Druga, Rastislav . Brain superoxide anion formation in immature rats during seizures: Protection by selected compounds . Experimental Neurology, 2012, Vol. 233, 1, p. 421-429 . IF = 4.645 [ASEP] [ doi ]
Šlamberová, R. - Mikulecká, Anna - Pometlová, M. - Schutová, B. - Hrubá, L. - Deykun, K. Sex differences in social interaction of methamphetamine-treated rats . Behavioural Pharmacology, 2011, Vol. 22, 7, p. 617-623 . IF = 2.720 [ASEP] [ doi ]
Tolner, E. A. - Hochman, D. W. - Hassinen, P. - Otáhal, Jakub - Gaily, E. - Haglund, M. M. - Kubová, Hana - Schuchmann, S. - Vanhatalo, S. - Kaila, K. Five percent CO2 is a potent, fast-acting inhalation anticonvulsant . Epilepsia, 2011, Vol. 52, 1, p. 104-114 . IF = 3.961 [ASEP] [ doi ]
Tichá, Kateřina - Mikulecká, Anna - Mareš, Pavel . Behavioral consequences of the mGlu5 receptor antagonist MTEP in immature rats . Pharmacology, Biochemistry and Behavior, 2011, Vol. 99, 4, p. 619-625 . IF = 2.532 [ASEP] [ doi ]
Mikulecká, Anna - Mareš, Pavel - Kubová, Hana . Rebound increase in seizure susceptibility but not isolation-induced calls after single administration of clonazepam and Ro 19-8022 in infant rats . Epilepsy and Behavior, 2011, Vol. 20, 1, p. 12-19 . IF = 2.335 [ASEP] [ doi ]
Flachs, Pavel - Rühl, R. - Hensler, Michal - Janovská, Petra - Zouhar, Petr - Kůs, Vladimír - Macek Jílková, Zuzana - Papp, E. - Kuda, Ondřej - Svobodová, Michaela - Rossmeisl, Martin - Tsenov, Grygoriy - Mohamed-Ali, V. - Kopecký, Jan . Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids . Diabetologia, 2011, Vol. 54, 10, p. 2626-2638 . IF = 6.814 [ASEP] [ doi ]
Tchekalarova, Jana - Kubová, Hana - Mareš, Pavel . Transient changes of cortical interhemispheric responses after repeated caffeine administration in immature rats . Physiological Research, 2011, Vol. 60, 6, p. 961-969 . IF = 1.555 [ASEP]

Kontakty

Fyziologický ústav AV ČR, v.v.i.
Oddělení vývojové epileptologie

Vídeňská 1083
14220 Praha 4
tel. +420 241 062 549
fax. +420 241 062 565
 

kubova@epilepsy.biomed.cas.cz

Lidé

doc. PharmDr. Hana Kubová, DrSc.
vedoucí oddělení
doc. MUDr. Jakub Otáhal, Ph.D.
zástupce vedoucí oddělení
RNDr. Jaroslava Folbergrová, DrSc.
vědecký pracovník
prof. MUDr. Přemysl Jiruška, Ph.D.
vědecký pracovník
prof. MUDr. Pavel Mareš, DrSc.
vědecký pracovník
RNDr. Nina Mikulecká, Ph.D.
vědecký pracovník
Mgr. Grygoriy Tsenov, Ph.D.
vědecký pracovník
MUDr. Petr Fábera 
postgraduální student
Ing. Jan Kudláček​ 
postgraduální student
Ing. et Ing. Antonín Pošusta​ 
postgraduální student
Mgr. Ewa Szczurowska​ 
postgraduální student
Mgr. Libor Uttl​ 
postgraduální student
Ing. Pavel Vlk 
postgraduální student
Bc. Lubica Demeterová 
pregraduální student
Bc. Kateřina Vondráková​ 
pregraduální student
  Blanka Čejková​​ 
technický pracovník
Eva Lažková​ 
technický pracovník
Irinka Necheva​​ 
technický pracovník
Ivana Rabasová​​​ 
sekretářka
  prof. MUDr. Rastislav Druga, DrSc.
externí vědecký pracovník
Thuy Hua
externí vědecký pracovník

© 2014 Fyziologický ústav AV ČR