Optical Biosensors

Focus

The team is engaged in the research of photonic and plasmonic (nano) structures and functional biomolecular files, the development of optical measuring methods and systems, the study of biomolecular interactions and detection of chemical and biological agents in areas such as medical diagnostics, food quality control or environmental monitoring.

Research projects

• Novel biophotonic tools for investigation of cellular processes
• Advanced plasmonic biosensors: towards the next-generation biomolecular interaction analysis
• Interactions of intracellular amyloid beta and diagnosis of Alzheimer disease

Complete overview of research projects

Publications

1. Z. Krištofiková, T. Špringer, E. Gedeonová, A. Hofmannová, J. Ríčný, L. Hromadková, M. Vyhnálek, J. Laczo, T. Nikolai, J. Hort, T. Petrásek, A. Stuchlík, K. Valeš, J. Klaschka,  J. Homola: Interactions of 17β-Hydroxysteroid Dehydrogenase Type 10 and Cyclophilin D in Alzheimer's Disease, Neurochemical Research, 45, 915–927(2020).
2. N. S. Lynn, T. Špringer, J. Slabý, B. Špačková, M. Gráfová, M. L. Ermini, J. Homola: Analyte transport to micro- and nano-plasmonic structures, Lab on a Chip, 19, 4117-4127 (2019).
3. O. Pastva, L. Chrastinová, M. Bocková, R. Kotlín, J. Suttnar, A. Hlaváčková, J. Štikarová, E.  Ceznerová, J. Čermák, J. Homola, J. E. Dyr: Hsp70 trap assay for detection of misfolded subproteome related to Myelodysplastic syndromes, Analytical Chemistry, 91, 14226-14230 (2019).
4. E. Hemmerová, T. Špringer, Z. Krištofiková, J. Homola: In vitro study of interaction of 17β-hydroxysteroid dehydrogenase type 10 and cyclophilin D and its potential implications for Alzheimer’s disease, Scientific Reports, 9, Article number 16700 (2019). 
5. L. Chrastinová, O. Pastva, M. Bocková, N. S. Lynn, P. Šácha, M. Hubálek, J. Suttnar, R. Kotlín, J. Štikarová, A. Hlaváčková, K. Pimková, J. Čermák, J. Homola, and J. E. Dyr: A new approach for the diagnosis of myelodysplastic syndrome subtypes based on protein interaction analysis, Scientific Reports, 9, Article number 12647 (2019).

Complete overview of publications