INSTITUTE OF PHYSIOLOGY CAS

PHD PROGRAMME 2020

CALL FOR APPLICATIONS

Application deadline: March 20, 2020

The applicant must complete an

Please select at least one choice from the

The perspective PhD candidates will be contacted by the April 18, 2020 by the principal investigator(s) they chose and the next steps of the selection process will be arranged directly with them.

PhD positions 2020
Master's thesis

Molecular mechanisms of signalling bias at muscarinic receptors

Laboratory of Neurochemistry

Laboratory of Neurochemistry PhD project: Molecular mechanisms of signalling bias at muscarinic receptors Muscarinic acetylcholine receptors are G-protein coupled receptors (GPCRs) located in the plasma membrane of many cell types of various tissues. These receptors mediate extracellular to… More

Triheteromeric NMDA receptors – physiological and pathophysiological functional properties

Laboratory of Cellular Neurophysiology

Laboratory of Cellular Neurophysiology PhD project: Triheteromeric NMDA receptors – physiological and pathophysiological functional properties Ionotropic glutamate receptors (iGluRs) mediate excitatory synaptic transmission and are essential for processes of learning and memory formation. … More

Computational analysis of surface mobility of NMDA receptors in hippocampal synapses

Laboratory of Computational Neuroscience

Laboratory of Computational Neuroscience PhD project: Computational analysis of surface mobility of NMDA receptors in hippocampal synapses In recent years, it has become clear that the structure of neuronal synapses is highly dynamical, with many of the molecular constituents turning over at a… More

Molecular mechanisms and functional consequences of P2X receptor activation in rat hypothalamus

Laboratory of Cellular and Molecular Neuroendocrinology

Laboratory of Cellular and molecular neuroendocrinology PhD project: Molecular mechanisms and functional consequences of P2X receptor activation in rat hypothalamus Purinergic P2X receptors are ligand gated ion channels activated by extracellular ATP. They play a role in neurotransmission,… More

Influence of proteins in the protection against tooth caries

Laboratory of Translational Metabolism

Laboratory of Translational Metabolism PhD project: Influence of proteins in the protection against tooth caries About 90% worldwide adults suffer from dental caries on enamel and root surfaces. The resistance of the lucky rest of population (10%) against the development of dental caries still… More

Characterization of clubfoot fibrotic tissue and its experimental releasing

Laboratory of Translational Metabolism

Laboratory of Translational metabolism PhD Project: Characterization of clubfoot fibrotic tissue and its experimental releasing Idiopathic pes equinovarus (also referred to as clubfoot) is a congenital deformity of the foot and lower leg. It is the most often hereditary orthopedic pathology with… More

Beneficial systemic effects of adipose tissue metabolism

Laboratory of Adipose Tissue Biology

Laboratory of Adipose Tissue Biology PhD project: Beneficial systemic effects of adipose tissue metabolism In all mammals including humans, two types of adipose tissue are recognized, white and brown adipose tissue (WAT and BAT, respectively), which are engaged in two major distinct and opposite… More

Impact of mitochondrial DNA diversity on metabolic phenotype and innate immunity

Laboratory of Bioenergetics

Laboratory of Bioenergetics PhD project: Impact of mitochondrial DNA diversity on metabolic phenotype and innate immunity Recently, metabolic syndrome has been associated with chronic, low-grade systemic inflammation, increased immunogenetic susceptibility and rise in circulating immune markers.… More

Molecular mechanisms of pathogenicity in ATP synthase disorders

Laboratory of Bioenergetics

Laboratory of Bioenergetics PhD project: Molecular mechanisms of pathogenicity in ATP synthase disorders Mutations in mitochondrial FoF1 ATP synthase lead to severe inborn errors of metabolism. As is the case with other mitochondrial diseases, one of the striking features is the tissue… More

Modulation of nociceptive signaling at spinal cord level

Laboratory of Pain Research

Laboratory of Functional Morphology PhD Project: Modulation of nociceptive signaling at spinal cord level The main research interest of our department is to study mechanisms of pain and to explore new possibilities of pain treatment, especially in chronic states. Our experimental… More

Healthy adipose tissue: role of FGF21 signaling

Laboratory of Adipose Tissue Biology

Laboratory of Adipose Tissue Biology PhD project: Healthy adipose tissue: role of FGF21 signaling In all mammals including humans, two types of adipose tissue are recognized, white and brown adipose tissue (WAT and BAT, respectively), which are engaged in two major distinct and opposite functions… More

Circadian transcriptome and proteome analyses of the fetal suprachiasmatic nuclei

Laboratory of Biological Rhythms

Laboratory of Biological Rhythms PhD project: Circadian transcriptome and proteome analyses of the fetal suprachiasmatic nuclei The lifestyle factors, such as irregular daily regime, exposure to light at night, shift work, sleep deprivation, stress, etc., become prevalent in modern society.… More

Targeted analysis of metabolic pathways - fluxomics by LC-MS/MS

Laboratory of Metabolism of Bioactive Lipids

Laboratory of Metabolism of Biactive Lipids PhD project: Targeted analysis of metabolic pathways - fluxomics by LC-MS/MS The focus of our lab is the metabolism and regulatory actions of bioactive lipids, specifically those related to pathways of glucose and lipid metabolism. We are interested in… More

New metabolic pathways involved in synthesis of anti-diabetic lipids

Laboratory of Metabolism of Bioactive Lipids

Laboratory of Metabolism of Biactive Lipids PhD project: New metabolic pathways involved in synthesis of anti-diabetic lipids The focus of our lab is the metabolism and regulatory actions of bioactive lipids, specifically those related to pathways of glucose and lipid metabolism. We are… More

Role of Inhibitory Factor IF1 in the regulation of pancreatic β-cell metabolism and mitochondrial morphology

Laboratory of Mitochondrial Physiology

Laboratory of Mitochondrial Physiology PhD project: Role of Inhibitory Factor IF1 in the regulation of pancreatic β-cell metabolism and mitochondrial morphology A unique function of pancreatic β-cells is insulin secretion and consequently also maintenance of glucose homeostasis. Several… More

Alteration of plasma membrane proteins and lipid composition by oxidative stress; studies of rat brain and model cell lines

Laboratory of Biomathematics

Laboratory of Biomathematics PhD project: Alteration of plasma membrane proteins and lipid composition by oxidative stress; studies of rat brain and model cell lines Most cell functions occur in or around membranes. Membranes represent a meeting point for lipids and proteins. The reactive… More

Collapsin response mediator proteins in microtubule dynamics and neural development

Laboratory of Molecular Neurobiology

Laboratory of Molecular neurobiology PhD project: Collapsin response mediator proteins in microtubule dynamics and neural development Precise regulation of neural development is essential for normal function of the adult nervous system and defects in its key parts - neuron migration, growth… More

Comprehensive analytical methods and bioinformatics tools for mass spectrometry-based metabolomics

Laboratory of Translational Metabolism

Laboratory of Translational Metabolism PhD project: Comprehensive analytical methods and bioinformatics tools for mass spectrometry-based metabolomics Untargeted metabolomics and lipidomics methods focus on the analysis of all the detectable metabolites in a sample, including chemical unknowns.… More

Novel analytical tools for the study of biological systems using mass spectrometry-based metabolomics

Laboratory of Translational Metabolism

Laboratory of Translational Metabolism PhD project: Novel analytical tools for the study of biological systems using mass spectrometry-based metabolomics Over the last decade, mass spectrometry-based metabolomics and lipidomics have become established as the key platforms for comprehensive… More

Physiological role of plasma-membrane transport systems in monovalent cation homeostasis

Laboratory of Membrane Transport

Laboratory of Membrane Transport PhD project: Physiological role of plasma-membrane transport systems in monovalent cation homeostasis The tight regulation of intracellular ion concentrations is crucial for all living cells. All types of cells employ various types of cation importers and… More

Information coding and transmission in neuronal systems

Laboratory of Computational Neuroscience

Laboratory of Computational Neuroscience PhD project: Information coding and transmission in neuronal systems The research in computational neuroscience has a long tradition, marked by the classical Lapicque, McCulloch-Pitts or Hodgkin-Huxley neuronal models. New topics have emerged alongside the… More