Institute of Organic Chemistry <br>and Biochemistry of the CAS

IOCB Fellowships – next submission deadline on 1 October

17 September 2020

IOCB Prague is opening up to 10 postdoctoral positions in chemistry and biochemistry per year funded by the IOCB Fellowship program. The fellowship is granted for one year with…

How to measure binding affinity of IGF2 analogues

11 September 2020

In adult humans, the physiological function of insulin-like growth factor 2 (IGF2) has not yet been entirely explained, even though it is the most abundant insulin-family protein…

Light-up nucleotide for visualization of DNA synthesis

23 August 2020

Fluorescent labelling of nucleic acids is a valuable tool with widespread usage in molecular and cellular biology as well as diagnostics. The team of researchers led by Michal…

NOV

Liblice 2020 – 55th Advances in Organic,…

4 November — 6 November 2020,…

Take the step towards a career in organic chemistry and biochemistry...

Apply for a postdoc

Reversible spatial and temporal control of lipid signaling

P. Gaur M. Galkin

S. Hauke

R. Redkin

C. Barnes

V. Shvadchak D. Yushchenko

Chemical Communications 56 (73): 10646-10649 (2020)

Herein, we introduce versatile molecular tools that enable specific delivery and visualization of photoswitchable lipids at cellular membranes, namely at the plasma membrane and internal membranes. These molecules were prepared by tethering ortho-nitrobenzyl-based fluorescent cages with a signaling lipid bearing an azobenzene photoswitch. They permit two sequential photocontrolled reactions, which are uncaging of a lipid analogue and then its repeated activation and deactivation. We used these molecules to activate GPR40 receptor transiently expressed in HeLa cells and demonstrated downstream modulation of intracellular Ca²⁺ levels.

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Synthesis and Cytotoxic and Antiviral Activity Profiling of All‐Four Isomeric Series of Pyrido‐Fused 7‐Deazapurine Ribonucleosides

L. Veselovská

N. Kudlová

S. Gurská

B. Lišková

M. Medvedíková

O. Hodek E. Tloušťová N. Milisavljevič M. Tichý P. Perlíková H. M. Kaiserová H. Mertlíková-Kaiserová J. Trylčová R. Pohl B. Klepetářová

P. Džubák

M. Hajdúch

M. Hocek

Chemistry - A European Journal 2020: Early View

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Cellular Signaling and Anti-Apoptotic Effects of Prolactin-Releasing Peptide and Its Analog on SH-SY5Y Cells

A. Zmeškalová A. Popelová A. Exnerová B. Železná J. Kuneš L. Maletínská

International Journal of Molecular Sciences 21 (17): 6343 (2020)

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It’s the Little Things (in Viral RNA)

J. Potužník H. Cahová

mBio 11: e02131-20 (2020)

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