Markéta Bocková, Ph.D.

Research interests:

Surface plasmon resonance (SPR) biosensors.

Functional coatings and assays for detection of biomolecules and investigation of biomolecular interactions.

Affinity biosensors for medical diagnostics. 

Awards:

2020: Bolzano prize of the Rector of Charles University in the category of natural sciences for doctoral thesis

Education:

2010 - 2019: Doctoral Study: Charles University, Faculty of Mathematics and Physics, Department of Biophysics
Thesis: Multifunctional biomolecular systems for parallelized analysis of biomolecular interaction

2007 - 2009: Master Study: Charles University, Faculty of Science, Department of Biochemistry
Thesis: Study of biomolecular interactions by the method of surface plasmon resonance

2004 - 2007: Bachelor study: Charles University, Faculty of Science, Department of Biochemistry
Thesis: Optical biosensors and study of biomolecular interactions.

Publications:

Journal papers:

1. O. Pastva, L. Chrastinová, M. Bocková, R. Kotlín, J. Suttnar, A. Hlaváčková, J. Štikarová, E.  Ceznerová, J. Čermák, J. Homola, J. E. Dyr: Hsp70 trap assay for detection of misfolded subproteome related to Myelodysplastic syndromes, Analytical Chemistry, 91, 14226-14230 (2019).
2. M. Kalousová, S. Dusilová-Sulková, A. Kuběna, O. Zakiyanov, K Levová, M. Bocková, E. Gedeonová, X. Chadtová Song, M. L. Ermini, T. Špringer, J. Homola, V. Tesař, and T. Zima: Pregnancy-associated plasma protein A2 in hemodialysis patients: significance for prognosis, Kidney and Blood Pressure Research, 42, 509-518 (2017)
3. L. Chrastinová, O. Pastva, M. Bocková, N. S. Lynn, P. Šácha, M. Hubálek, J. Suttnar, R. Kotlín, J. Štikarová, A. Hlaváčková, K. Pimková, J. Čermák, J. Homola, and J. E. Dyr: A new approach for the diagnosis of myelodysplastic syndrome subtypes based on protein interaction analysis, Scientific Reports, 9, Article number 12647 (2019).
4. M. Bocková, J. Slabý, T. Špringer, J. Homola: Advances in surface plasmon resonance imaging and microscopy and their biological applications, Annual Review of Analytical Chemistry, 12, 151–176 (2019).
5. B. Špačková, P. Wrobel, M. Bocková, J. Homola: Optical biosensors based on plasmonic nanostructures: a review, Proceedings of the IEEE, 104, 2380–2408 (2016).
6. C. Bessa-Pereira, M. Bocková, R. F. Santos, A. M. Santos, M. Martins de Araújo, L. Oliveira, J. Homola, A. M. Carmo: The scavenger receptor SSc5D physically interacts with bacteria through the SRCR-containing N-terminal domain, Frontiers in Immunology, 7, Article 416, 1-9 (2016).
7. M. Bocková, X. Xue Chadtová Song, E. Gedeonová, K. Levová, M. Kalousová, T. Zima, J. Homola: Surface plasmon resonance biosensor for detection of pregnancy associated plasma protein A2 in clinical samples, Analytical and Bioanalytical Chemistry, 408, 7265–7269.
8. N. S. Lynn, M. Bocková, P. Adam, J. Homola: Biosensor enhancement using grooved micromixers: part II, experimental studies, Analytical Chemistry, 87, 5524-5530 (2015).
9. M. Bocková, T. Špringer, I. Nečasová, J. Nunvar, B. Schneider, and J. Homola: Monitoring RAYT activity by surface plasmon resonance biosensor, Analytical and Bioanalytical Chemistry, 407, 3985-3993 (2015).
10. H. Vaisocherová, I. Víšová, M. Bocková, T. Špringer, M. L. Ermini, X. Song, Z. Krejčík, L. Chrastinová, O. Pastva, K. Pimková, M. Dostálová Merkerová, J. E. Dyr, and J. Homola: Rapid and sensitive detection of multiple MicroRNAs in cell lysate by low-fouling surface plasmon resonance biosensor, Biosensors and Bioelectronics, 70, 226–231 (2015).
11. N. S. Lynn Jr., J. Martínez-López, M. Bocková, P. Adam, V. Coello, H. R. Siller, J. Homola: Biosensing enhancement using passive mixing structures for microarray-based sensors, Biosensors and Bioelectronics, 54 (2014) 506-514.
12. T. Špringer, M. Bocková, J. Homola: Label-Free Biosensing in Complex Media: A Referencing Approach, Analytical Chemistry, 85 (2013) 5637–5640.
13. Z. Krištofiková, D. Řípová, A. Bartoš, M. Bocková, K. Hegnerová, J. Říčný, L. Čechová, M. Vrajová, J. Homola: Neuroinflammation and Complexes of 17ß-Hydroxysteroid Dehydrogenase type 10 – Amyloid ß in Alzheimer´s Disease, Current Alzheimer Research, 10 (2013) 165-173.
14. M. Vala, R. Robelek, M. Bocková, J. Wegener, J. Homola: Real-time label-free monitoring of the cellular response to osmotic stress using conventional and long-range surface plasmons, Biosensors and Bioelectronics, Biosensors and Bioelectronics 40 (2013) 417–421.
15. P. Kvasnička, K. Chadt, M. Vala, M. Bocková, and J. Homola: Toward single-molecule detection with sensors based on propagating surface plasmons, Optics letters, 37 (2012) 163 – 165. 
16. K. Pimková, M. Bocková, K. Hegnerová, J. Suttnar, J. Čermák, J. Homola, J. E. Dyr: Surface plasmon resonance biosensor for the detection of VEGFR-1—a protein marker of myelodysplastic          syndromes, Analytical and Bioanalytical Chemistry, 402 (2012) 381–387.
17. H. Šípová, M. Piliarik, M. Vala, K. Chadt, P. Adam, M. Bocková, K. Hegnerová, J. Homola: Portable Surface Plasmon Resonance Biosensor for Detection of Nucleic Acids, Procedia Engineering, 25 (2011) 148-151. 
18. M. Piliarik, M. Bocková, J. Homola: Surface plasmon resonance biosensor for parallelized detection of protein biomarkers in diluted blood plasma,  Biosensors and Bioelectronics, 26 (2010) 1656-1661.
19. S. Herranz, M. Bocková, M. D. Marazuela, J. Homola, M. C. Moreno-Bondi: An SPR biosensor for the detection of microcystins in drinking water, Analytical and Bioanalytical Chemistry 398 (2010) 2625–2634. 
20. Z. Krištofiková, M. Bocková, K. Hegnerová, A. Bartoš, J. Klaschka, J. Říčný, D. Řípová, J. Homola: Enhanced levels of mitochondrial enzyme 17ß-hydroxysteroid dehydrogenase type 10 in patients with Alzheimer disease and multiple sclerosis, Molecular Biosystems 5, (2009) 1174-1179.
21. K. Hegnerová, M. Bocková, H. Vaisocherová, Z. Krištofiková, J. Říčný, D. Řípová, J. Homola: Surface plasmon resonance biosensors for detection of Alzheimer disease biomarkers, Sensors and Actuators B-Chemical. 139, (2009) 69-73.
22. H. Vaisocherová, A. Zítová, M. Lachmanová, J. Štěpánek, Š. Králíková, R. Liboska, D. Rejman, I. Rosenberg, and J. Homola, Investigating oligonucleotide interactions at subnanomolar level by surface plasmon resonance biosensor, Biopolymers, 82 (2006), 394 – 398.