Laboratory of Neurochemistry
PhD project: Molecular mechanisms of signalling bias at muscarinic receptors
Muscarinic acetylcholine receptors are G-protein coupled receptors (GPCRs) located in the plasma membrane of many cell types of various tissues. These receptors mediate extracellular to…
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Laboratory of Cellular Neurophysiology
PhD project: Triheteromeric NMDA receptors – physiological and pathophysiological functional properties
Ionotropic glutamate receptors (iGluRs) mediate excitatory synaptic transmission and are essential for processes of learning and memory formation. …
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Laboratory of Computational Neuroscience
PhD project: Computational analysis of surface mobility of NMDA receptors in hippocampal synapses
In recent years, it has become clear that the structure of neuronal synapses is highly dynamical, with many of the molecular constituents turning over at a…
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Laboratory of Cellular and molecular neuroendocrinology
PhD project: Molecular mechanisms and functional consequences of P2X receptor activation in rat hypothalamus
Purinergic P2X receptors are ligand gated ion channels activated by extracellular ATP. They play a role in neurotransmission,…
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Laboratory of Translational Metabolism
PhD project: Influence of proteins in the protection against tooth caries
About 90% worldwide adults suffer from dental caries on enamel and root surfaces. The resistance of the lucky rest of population (10%) against the development of dental caries still…
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Laboratory of Translational metabolism
PhD Project: Characterization of clubfoot fibrotic tissue and its experimental releasing
Idiopathic pes equinovarus (also referred to as clubfoot) is a congenital deformity of the foot and lower leg. It is the most often hereditary orthopedic pathology with…
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Laboratory of Adipose Tissue Biology
PhD project: Beneficial systemic effects of adipose tissue metabolism
In all mammals including humans, two types of adipose tissue are recognized, white and brown adipose tissue (WAT and BAT, respectively), which are engaged in two major distinct and opposite…
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Laboratory of Bioenergetics
PhD project: Impact of mitochondrial DNA diversity on metabolic phenotype and innate immunity
Recently, metabolic syndrome has been associated with chronic, low-grade systemic inflammation, increased immunogenetic susceptibility and rise in circulating immune markers.…
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Laboratory of Bioenergetics
PhD project: Molecular mechanisms of pathogenicity in ATP synthase disorders
Mutations in mitochondrial FoF1 ATP synthase lead to severe inborn errors of metabolism. As is the case with other mitochondrial diseases, one of the striking features is the tissue…
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Laboratory of Functional Morphology
PhD Project: Modulation of nociceptive signaling at spinal cord level
The main research interest of our department is to study mechanisms of pain and to explore new possibilities of pain treatment, especially in chronic states. Our experimental…
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Laboratory of Adipose Tissue Biology
PhD project: Healthy adipose tissue: role of FGF21 signaling
In all mammals including humans, two types of adipose tissue are recognized, white and brown adipose tissue (WAT and BAT, respectively), which are engaged in two major distinct and opposite functions…
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Laboratory of Biological Rhythms
PhD project: Circadian transcriptome and proteome analyses of the fetal suprachiasmatic nuclei
The lifestyle factors, such as irregular daily regime, exposure to light at night, shift work, sleep deprivation, stress, etc., become prevalent in modern society.…
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Laboratory of Metabolism of Biactive Lipids
PhD project: Targeted analysis of metabolic pathways - fluxomics by LC-MS/MS
The focus of our lab is the metabolism and regulatory actions of bioactive lipids, specifically those related to pathways of glucose and lipid metabolism. We are interested in…
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Laboratory of Metabolism of Biactive Lipids
PhD project: New metabolic pathways involved in synthesis of anti-diabetic lipids
The focus of our lab is the metabolism and regulatory actions of bioactive lipids, specifically those related to pathways of glucose and lipid metabolism. We are…
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Laboratory of Mitochondrial Physiology
PhD project: Role of Inhibitory Factor IF1 in the regulation of pancreatic β-cell metabolism and mitochondrial morphology
A unique function of pancreatic β-cells is insulin secretion and consequently also maintenance of glucose homeostasis. Several factors…
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Laboratory of Biomathematics
PhD project: Alteration of plasma membrane proteins and lipid composition by oxidative stress; studies of rat brain and model cell lines
Most cell functions occur in or around membranes. Membranes represent a meeting point for lipids and proteins. The reactive…
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Laboratory of Molecular neurobiology
PhD project: Collapsin response mediator proteins in microtubule dynamics and neural development
Precise regulation of neural development is essential for normal function of the adult nervous system and defects in its key parts - neuron migration, growth and…
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Laboratory of Translational Metabolism
PhD project: Comprehensive analytical methods and bioinformatics tools for mass spectrometry-based metabolomics
Untargeted metabolomics and lipidomics methods focus on the analysis of all the detectable metabolites in a sample, including chemical unknowns.…
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Laboratory of Translational Metabolism
PhD project: Novel analytical tools for the study of biological systems using mass spectrometry-based metabolomics
Over the last decade, mass spectrometry-based metabolomics and lipidomics have become established as the key platforms for comprehensive…
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Laboratory of Membrane Transport
PhD project: Physiological role of plasma-membrane transport systems in monovalent cation homeostasis
The tight regulation of intracellular ion concentrations is crucial for all living cells. All types of cells employ various types of cation importers and…
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Laboratory of Computational Neuroscience
PhD project: Information coding and transmission in neuronal systems
The research in computational neuroscience has a long tradition, marked by the classical Lapicque, McCulloch-Pitts or Hodgkin-Huxley neuronal models. New topics have emerged alongside the…
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