We investigate molecular mechanisms of nociception and thermosensation by focusing on thermosensitive transient receptor potential (TRP) ion channels. These channels are specifically expressed in primary nociceptive neurons and work in concert to detect potentially damaging stimuli and transduce them into pain signalling. The goal of our research is to understand the physiological or pathophysiological significance of specific subclasses of TRP ion channels involved in the detection of noxious thermal, mechanical and chemical stimuli, through deciphering molecular and biophysical principles of their operational features.

Temperature thresholds for activation range of thermosensitive TRP ion channels in mammals (TRPM8, TRPC5, TRPA1, TRPM2-5, TRPV1-4), from cold to hot. Temperatures below 15° and over 43°C cause pain sensation in mammals, therefore, several of the thermosensitive TRP can be viewed as nociceptive detectors.

Ongoing Studies

• Molecular mechanisms of TRPV1, TRPV2 and TRPA1 activation
• Molecular mechanisms of thermosensation
• TRPV1 and TRPA1 as intrinsically voltage-sensitive ion channels