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Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein
PLOS Pathogens 16 (12): e1009100 (2020)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19). SARS-CoV-2 is a single-stranded positive-sense RNA virus. Like other coronaviruses, SARS-CoV-2 has an unusually large genome that encodes four structural proteins and sixteen nonstructural proteins. The structural nucleocapsid phosphoprotein N is essential for linking the viral genome to the viral membrane. Both N-terminal RNA binding (N-NTD) and C-terminal dimerization domains are involved in capturing the RNA genome and, the intrinsically disordered region between these domains anchors the ribonucleoprotein complex to the viral membrane. Here, we characterized the structure of the N-NTD and its interaction with RNA using NMR spectroscopy. We observed a positively charged canyon on the surface of the N-NTD that might serve as a putative RNA binding site similarly to other coronaviruses. The subsequent NMR titrations using single-stranded and double-stranded…
Flow cytometric determination of cell cycle progression via direct labeling of replicated DNA
Analytical Biochemistry 614: 114002 (2021)
Multipodal insulin mimetics built on adamantane or proline scaffolds
Bioorganic Chemistry 107: 104548 (2021)
1,2,4-Thiadiazole acyclic nucleoside phosphonates as inhibitors of cysteine dependent enzymes cathepsin K and GSK-3β
Bioorganic and Medicinal Chemistry 32: Early View (2021)