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GPR10 gene deletion in mice increases basal neuronal activity, disturbs insulin sensitivity and alters lipid homeostasis
Gene 774: 145427 (2021)
G-protein-coupled receptor GPR10 is expressed in brain areas regulating energy metabolism. In this study, the effects of GPR10 gene deficiency on energy homeostasis in mice of both sexes fed either standard chow or a high-fat diet (HFD) were studied, with a focus on neuronal activation of PrRP neurons, and adipose tissue and liver metabolism. GPR10 deficiency in males upregulated the phasic and tonic activity of PrRP neurons in the nucleus of the solitary tract. GPR10 knockout (KO) males on a standard diet displayed a higher body weight than their wild-type (WT) littermates due to an increase in adipose tissue mass; however, HFD feeding did not cause weight differences between genotypes. Expression of lipogenesis genes was suppressed in the subcutaneous adipose tissue of GPR10 KO males. In contrast, GPR10 KO females did not differ in body weight from their WT controls, but showed elevated expression of lipid metabolism genes in the liver and subcutaneous adipose tissue compared to WT…
Reversible photo- and thermal-effects on the luminescence of gold nanoclusters: implications for nanothermometry
Physical Chemistry Chemical Physics 23 (20): 11954-11960 (2021)
Electrochemical Cleavage of Carbon-Chlorine Bonds in Multiply Bridge-Chlorinated Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acids
ChemElectroChem 2021: Early View
CoLiDe: Combinatorial Library Design tool for probing protein sequence space
Bioinformatics 37 (4): 482–489 (2021)
Inverse heavy-atom effect in near infrared photoluminescent gold nanoclusters
Nanoscale 13 (23): 10462-10467 (2021)