The Bioinformatics group led by Jiří Vondrášek from IOCB Prague has developed the Amino Acid Interactions (INTAA) web server investigating the energetics of amino acid interactions in the 3D structures of biomolecules.
Recently, scientists released a new version of the application and introduced a new continuum solvation model for the accurate representation of electrostatic interactions in aqueous media. They also added a pipeline to estimate the evolutionary conservation in protein chains, which makes it possible to study the residues’ physical and evolutionary roles within the biomolecular structures using a single web service.
The new functionalities together with novel visualization options have been reported in Nucleic Acids Research.
The original paper:
- Vymětal, J.; Jakubec, D.; Galgonek, J.; Vondrášek, J. Amino Acid Interactions (INTAA) web server v2.0: a single service for computation of energetics and conservation in biomolecular 3D structures. Nucleic Acids Research 2021, 49, W15-W20. https://doi.org/10.1093/nar/gkab377
