We are enhancing our
understanding
of the genetic basis for
human diseases

What can we help you with

Microinjection

Model Generation

Genetically modified rodent models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. 
Phenotyping

Phenotyping

The genomes of humans, mice and other species have been completely sequenced, yet the knowledge of genome sequences as such does not shed light on questions concerning the functions of these sequences. 

Animal Facility

The Animal Facility Module of the Czech Center for Phenogenomics is based on the latest advances in housing, breeding and care of laboratory mice and rats. 
Mouse tumors

Preclinical Testing

The Czech Centre for Phenogenomics can offer a very broad portfolio of highly standardized assays useful for preclinical studies on rodents including established disease models. 

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Latest News

24. 11. 2021

Sharing & archiving of genetically altered mice: opportunities for reduction and refinement

International experts on breeding, managing and archiving colonies gathered in the expert working group of the UK National Centre for the Replacement & Refinement & Reduction of Animals in Research has updated the document “Sharing & archiving of genetically altered mice: opportunities for reduction and refinement”. The updated document reflects how current best practices in…

18. 11. 2021

We are searching new colleagues – bioimaging, metabolism, histology, bioinformatics

Two positions are available in our Bioimaging unit: Bioimaging Lab Technician (junior) + Bioimaging Research Specialist. Moreover, we seek a Metabolism Lab Technician and a Histology Lab Technician and Data Analyst to help us improve the research data database. For more details go to our Career page.

06. 10. 2021

Three CCP members joined COST Actions

Jan Rozman joined the new COST Action CA20135 – Improving biomedical research by automated behaviour monitoring in the animal home-cage. The Action will assess the potential of these technologies, develop user guidelines and standard operating procedures and identify needs for further technological development. CCP will bring knowledge in preclinical testing in the stroke research field…

About Czech Centre for Phenogenomics

Genetically modified mouse models have become a key tool in basic and biomedical research. The ability to engineer the mouse genome has greatly transformed biomedical research in the last decade. Crucial for this technology is the ability to control the expression of genes of interest. It is possible to increase or decrease gene expression, or eliminate the expression of a gene completely.

Transgenic and gene knockout/knockin technologies have become important experimental tools for assigning functions to genes at the level of whole complexity of organism, creating models of genetic disorders, evaluating effects drugs and toxins, thus helping to answer fundamental issues in basic and applied research.