Pracovní listy na téma Jak postupovat při léčbě geneticky podmíněné choroby je v příloze pod galerií obrázků.
Pěkná videa popisující funkci CRISPR-Cas volně přístupná na you tube
https://www.youtube.com/watch?v=2pp17E4E-O8
Citovaná a doporučená literatura a internetové zdroje:
CAVAZZANA-CALVO, Marina, et al. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science, 2000, 288.5466: 669-672.
CHARPENTIER, Emmanuelle; DOUDNA, Jennifer A. Biotechnology: Rewriting a genome. Nature, 2013, 495.7439: 50-51.
HACEIN-BEY-ABINA, Salima, et al. A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. New England Journal of Medicine, 2003, 348.3: 255-256.
JINEK, Martin, et al. A programmable dual-RNA–guided DNA endonuclease in adaptive bacterial immunity. Science, 2012, 337.6096: 816-821.
LIANG, Puping, et al. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein & cell, 2015, 6.5: 363-372.
NELSON, Christopher E., et al. In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy. Science, 2016, 351.6271: 403-407.
PFEFFER, Sébastien, et al. Identification of virus-encoded microRNAs. Science, 2004, 304.5671: 734-736.
SU, Shu, et al. CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients. Scientific reports, 2016, 6: 20070.
