The research at our Laboratory focuses on the pathophysiology of epilepsy and epileptic seizures in adulthood and particularly in the developing brain. In our research we are utilizing modern electrophysiological, imaging, biochemical and pharmacological techniques. To elucidate the cellular and network mechanisms involved in epilepsy and to increase the translational potential of new observations we are using extensively chronic models of acquired epilepsy and also genetic models and also collaborate with leading epilepsy centres.
Our primary research topics are:
- Consequences of brain injury during early stages of the brain development
- Mechanisms responsible for seizure initiation and termination.
- Impact of seizures on the developing brain
- Development of new diagnostic techniques of epilepsy
- Cognitive and behavioural consequences of epilepsy
- The role of oxidative stress in pathogenesis of epilepsy and seizures during the development
- Impact of antiepileptic therapy of the brain development
- Age-specific mechanisms of seizure initiation and propagation
Projects
Brain-damaging insult triggers a cascade of molecular, cellular and structural changes that eventually lead to behavioral alterations and development of epilepsy. The response to the particular brain insult is highly age-dependent. Our aim is to study effects of early insults on the brain development at the molecular, cellular, and circuitry levels (maturation of receptors or ionic channel structures, vascularisation, myelination, circuitry maturation, etc.) and consequently on maturation of more complex brain functions (cognitive functions, sensorimotor skills, social and emotional behavior, brain excitability, etc.). Results of our research can be used to develop age specific pharmacological strategies for prevention of epilepsy development and disturbances of brain function.
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Systems important for brain excitability and its regulation mature for a long period of postnatal life.
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Period of perinatal and early postnatal development represents critical time for future brain functions and capabilities, as brain plasticity permits experiences to shape the immature brain.
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Oxidative stress and mitochondrial dysfunction are implicated in the pathogenesis of many neurological disorders, including epilepsy.
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Achievements
Epileptology European Award 2016 was awarded prof. Pavel Mareš.
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Publications
Salaj; M. - Barinka; F. - Kubová; Hana - Druga; Rastislav
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Differences in Expression of Calcium Binding Proteins in the Perirhinal and Retrosplenial Cortex of the Rat
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Physiological Research. 2021; 70(2); 273-285
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IF = 1.881
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doi
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Petrásek; T. - Vojtěchová; I. - Klovrza; O. - Tučková; K. - Vejmola; Č. - Rak; J. - Šuláková; A. - Kaping; D. - Bernhardt; N. - de Vries; P. J. - Otáhal; Jakub - Waltereit; R.
mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus
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Journal of Neurodevelopmental Disorders. 2021; 13(1)); 14
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IF = 4.025
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doi
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Mareš; Pavel - Tsenov; Grygoriy - Kubová; Hana
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Anticonvulsant Action of GluN2A-Preferring Antagonist PEAQX in Developing Rats
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Pharmaceutics. 2021; 13(3)); 415
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IF = 6.321
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doi
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Mareš; Pavel - Kubová; Hana
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Perampanel exhibits anticonvulsant action against pentylentetrazol-induced seizures in immature rats
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Epilepsy Research. 2021; 169(Jan)); 106523
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IF = 3.045
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doi
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Mareš; Pavel - Kozlová; Lucie - Mikulecká; Anna - Kubová; Hana
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The GluN2B-Selective Antagonist Ro 25-6981 Is Effective against PTZ-Induced Seizures and Safe for Further Development in Infantile Rats
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Pharmaceutics. 2021; 13(9)); 1482
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IF = 6.321
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doi
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