Význam mezinárodní spolupráce
Základní výzkum je svou podstatou mezinárodní činnost, a proto hraje i ve výzkumu Biofyzikálního ústavu AV ČR, v.v.i. (BFÚ) významnou roli mezinárodní spolupráce. Tato spolupráce je důležitá pro všechna oddělení a je podmínkou toho, aby oddělení mohlo v BFÚ samostatně existovat. Jak je vidět z přiloženého seznamu, všechna oddělení produkují významnou část svých publikací ve spolupráci se zahraničními partnery. Všechna oddělení s výjímkou DSNA měla take v období od roku 2005 mezinárodní projekty; většina oddělení připravila nebo se účastnila přípravy mezinárodní vědecké akce (v dlouhodobé perspektivě se na pořádání mezinárodních konferencí účastní prakticky všechna oddělení).
Několik zahraničních projektů lze označit jako prestižní. Byly to EU projekty 6th FP, LSHC-CT-2004- 502983 „Mutant p53 a target for improved cancer treatment“, kde řešitelem za BFÚ byl E. Paleček a 6th FP-STREP, LSHG-CT-2003-503441 „3D Genome“, řešitel za BFÚ byl S. Kozubek. Dále projekt financovany National Institutes of Health, NIH, USA s názvem „Mechanistic Studies on New Platinum Clinical Agents“, který řešil V. Brabec, projekt financovaný z Howard Hughes Medical Institute, USA „Platinum and ruthenium compounds. From DNA damage to cancer chemotherapy „ s řešitelkou J. Kašpárkovou. Senior Research Fellowship z The Wellcome Trust obdržel J. Šponer. Velmi významná je role V. Brabce jako koordinátora programu COST – European Cooperation in Science and Technology (EC/NSF) s názvem „Metallo-Drug Design and Action“. V tomto programu figuruje 54 laboratoří z Evropy, Izraele a Austrálie.
BFÚ organizoval nebo se podílel na organizaci 15 mezinárodních akcí. Pozoruhodnou tradicí již získala konference „Analytická cytometrie“ představující oficiální akci České společnosti pro analytickou cytologii, jež byla založena v BFÚ Aloisem Kozubíkem a dalšími členy jeho oddělení. Těchto akcí se účastní velký počet mladých vědců, kteří tak mají možnost diskutovat své výsledky se zahraničními vědci.
Mezinárodní spolupráce byla v uplynulých 5 letech důležitá nejen pro výměnu idejí, ale také pro realizaci některých experimentů, které nebylo možné provést v BFÚ nebo tam, kde v BFÚ nebyla dostatečná zkušenost pro jejich provedení. Přínos těchto spoluprací pro BFÚ je tedy zásadní, neboť přibližně polovina významných publikací s IF>4 vzniká v nějaké spolupráci. Prestižní spolupráce s významnými světovými laboratořemi je samozřejmě pro ústav velkým přínosem; je však potřeba zdůraznit, že řada hodnotných publikací vzniká na půdě BFÚ: 92 publikací s IF nad 4 vzniklo za posledních 5 let významnou měrou na půdě BFÚ (korespondující autor a většinou i první autor byli z BFÚ).
Uznání v zahraničí spočívá v celé řadě zvaných pobytů a přednášek na významných pracovištích nebo kongresech u pracovníků prakticky ze všech oddělení, jsou prováděny korektury článků, vědci BFÚ jsou členy mezinárodních společností apod. Nejvýznamnější je však citovanost prací: BFÚ má na publikace z let 2005-2009 již 4500 citací, což je na ústav velikosti BFÚ a danou oblast výzkumu výsledek v ČR pravděpodobně nejlepší.
Akce s mezinárodní účasti organizované nebo spolu-organizované BFÚ za období 2005–2009
Mezinárodní projekty řešené v BFÚ AV ČR v období 2005–2009
Číslo | Název programu | Název projektu | Koordinátor/ | Spolupracovník | Účastnícké země |
1 | EC 5th FP, Marie Curie RTN (2002 – 2007) | Structural effects arising from major groove DNA recognition by metallo-supramolecular cylinders (MARCY) | Michael J. Hannon, University of Warwick, UK | Viktor Brabec, Institute of Biophysics, AS CR, Brno, Czech Republic | United Kingdom, Sweden, Norway, Spain |
2 | Grants for Biomedical Research (HHMI, USA) | Basis for new structure-pharmacological relationship of platinum drugs | Jana Kašpárková, Institute of Biophysics, AS CR, Brno | N/A | N/A |
3 | National Institutes of Health, NIH, USA (1998 – 2007) | Mechanistic Studies on New Platinum Clinical Agents | Nicholas P. Farrell, Virginia Commonwealth University, Richmond, USA | Viktor Brabec, Institute of Biophysics, AS CR, Brno, Czech Republic | USA |
4 | Collaborative Research Initiative Grant (The Wellcome Trust) (2005 – 2008) | Platinum and ruthenium complexes. From DNA damage to cancer chemotherapy
| N/A
| Viktor Brabec, IBP, AS CR, Brno and Peter J. Sadler, Univ Edinburgh | United Kingdom |
5 | Grants for Biomedical Research (Howard Hughes Medical Institute, USA) (2006 – 2010) | Platinum and ruthenium compounds. From DNA damage to cancer chemotherapy
| Jana Kašpárková, Institute of Biophysics, AS CR, Brno | N/A | N/A |
6 | COST – European Cooperation in Science and Technology (EC/NSF) (2006 – 2011) | Metallo-Drug Design and Action
| Viktor Brabec, Institute of Biophysics, AS CR, Brno, Czech Republic | Viktor Brabec, Institute of Biophysics, AS CR, Brno, Czech Republic | AT, BE, CHE, DE, DK, ES, FR, GR, HU, IE, IL, IT, NL, NO, PL, PT, RO, SE, SI, TR, UK
|
7 | National Science Foundation (USA) Academy of Sciences of the Czech Republic | Platinum metal complexes as DNA-protein cross-linking agents | Viktor Brabec, Institute of Biophysics, AS CR, Brno, Czech Republic | Viktor Brabec, Institute of Biophysics, AS CR, Brno, Czech Republic | USA
|
8 | Ministry of Education of the CR/Ministry of Education of China | Transition metal-based anticancer compounds. From mechanistic studies to innovatory cancer chemotherapy | Viktor Brabec, Institute of Biophysics, AS CR, Brno, Czech Republic | Viktor Brabec, Institute of Biophysics, AS CR, Brno, Czech Republic | China
|
9 | KONTAKT-AIP, Czech-Greek intergovernmental scientific and technical cooperation, 2006-2007 | Synthesis, characterization and study of the nucleolytic activity of novel selective chemical nucleases, based on heteronuclear metallopeptides Ru(II)-Ni(II) | Jaroslav Malina, Institute of Biophysics, AS CR, Brno, Czech Republic | Jaroslav Malina, Institute of Biophysics, AS CR, Brno, Czech Republic | Greece | |
10 | FP6-MOBILITY, Sixth Framework Programme, Marie Curie European Reintegration Grants (ERG) | 6FP EU, MERG-6-CT-2005-014875, European Reintegration Grant, „Novel interactions of mutant p53 with genomic DNA in vitro and in vivo“, | Emil Paleček, Institute of Biophysics, AS CR, Brno | Marie Brázdová, Institute of Biophysics, AS CR, Brno, Czech Republic | CzechRepublic | |
11 | EU LSHC-CT-2004- 502983 | Mutant p53 a target for improved cancer treatment | Klas Wiman,Karolinska Institute, Sweden | Emil Paleček, Institute of Biophysics, AS CR, Brno, Czech Republic | Sweden, Holland, Germany, Italy, Norway, Israel, England, France, Estonia, Czech Republic | |
12 | Sixth Framework Programme- Marie Curie Host Fellowships - Transfer of knowledge (TOK) - Development Scheme | Newchemical and biochemical sensors for analysis of food, enviromental and medical samples | Jerzy Radecki, Institute of animal reproduction and food research - Polish Academy of Sciences, Olsztyn, Poland
| Emil Paleček, Institute of Biophysics, AS CR, Brno, Czech Republic | Poland, Czech Republic, England | |
13 | ME - KONTAKT (1996-2012) | Interactions of proteins and nucleic acids with surfaces. New tools for biomedicine. | J.Wang, Dept.Nanoengineering, La Jolla, CA 92093-0448, USA | Emil Paleček, Institute of Biophysics, AS CR, Brno, Czech Republic | USA, Czech Republic | |
14 | Programme of International Collaboration of the AS CR | Aggregation of alpha synuclein in Parkinson's disease | Veronika Ostatná,Institute of Biophysics, AS CR, Brno, Czech Republic | Emil Paleček, Institute of Biophysics, AS CR, Brno, Czech Republic | Germany, Czech Republic | |
15 | KONTAKT ME 685 Ministry of Education of the CR - Bilateral Czech-Greek Cooperation | Development of methods and construction of sensors for the detection of interaction of DNA with drugs | Vladimír Vetterl, Institute of Biophysics, AS CR, Brno, Czech Republic | Vladimír Vetterl, Institute of Biophysics, AS CR, Brno, Czech Republic
| Greece, Czech Republic | |
16 | KONTAKT 94Ministry of Education of the CR -Bilateral Czech-Slovak Cooperation | Study of DNA hybridization at surfaces | Vladimír Vetterl, Institute of Biophysics, AS CR, Brno, Czech Republic | Vladimír Vetterl, Institute of Biophysics, AS CR, Brno, Czech Republic
| Greece, Czech Republic | |
17 | KONTAKT 7_2006_19 Ministry of Education of the CR - Bilateral Czech-Greek Scientific-Technical Cooperation
| Application of biophysical methods in biotechnology and biomedicine
| Vladimír Vetterl, Institute of Biophysics, AS CR, Brno, Czech Republic
| Vladimír Vetterl, Institute of Biophysics, AS CR, Brno, Czech Republic
| Slovakia, Czech Republic |
18 | KONTAKT ME 920 Ministry of Education of the CR - Bilateral Czech-Greek Cooperation | Application of biophysical methods in biotechnology and biomedicine | Vladimír Vetterl, Institute of Biophysics, AS CR, Brno, Czech Republic | Vladimír Vetterl, Institute of Biophysics, AS CR, Brno, Czech Republic
| Slovakia, Czech Republic |
19 | Barrande Czech Republic-France 2005-2006 | Studies of genetic interactions (changes) in synthetic Nicotiana allopolyploid plants | Ales Kovarik (IBP), Marie Angele Grandbastien (INRA Versailles) | Ales Kovarik (IBP), Marie Angele Grandbastien
| France, Czech Republic |
20 | Barrande Czech Republic-France 2008-2009 | Structural and functional analysis of ribosomal RNA genes during stabilisation of synthetic allopolyploid Brassica napus | Ales Kovarik (IBP), Anne-Marie Chevre (INRA Rennes) | Ales Kovarik (IBP), Anne-Marie Chevre (INRA Rennes) | France, Czech Republic |
21 | EU 6th FP-STREP, LSHG-CT-2003-503441 | 3D Genome | Roel van Driel (Univ of Amsterdam, The Netherlands) | Stanislav Kozubek, Institute of Biophysics, AS CR, Brno, Czech Republic | Germany, Belgium, France, Czech Republic |
22 | Marie Curie Fellowship (2007-8) | Telomere-associated proteins inA.thaliana | Jiří Fajkus, Institute of Biophysics, AS CR, Brno, Czech Republic | Jiří Fajkus, Institute of Biophysics, AS CR, Brno, Czech Republic | Great Britain, Czech Republic. |
23 | Programme of International Collaboration of the AS CR | Characterization of plant telomerase in vivo and in vitro by reconstitution and substitution experiments | Jiří Fajkus, Institute of Biophysics, AS CR, Brno, Czech Republic | I.Schubert, co-principal investigator | Germany, Czech Republic |
24 | CNRS-AS CR project | Topoisomerase IIaand HMGB1: involvement in chromatin structure and sensitivity of human cells to anticancer drugs | PI from France: Claire Gaillard | PI from Czech Republic: Michal Štros | France, Czech Republic |
25 | Programm des Projektbezogenen Personenaustauchs mit Tschechien | Disruption of contact inhibition by polyaromatic compounds (2004-2005) | C. Dietrich JGU, Mainz, SRN | J. Vondráček, Institute of Biophysics, AS CR, Brno, Czech Republic | CzechRepublic,Germany |
| Programm des Projektbezogenen Personenaustauchs mit Tschechien | Analysis of the cross talk between cytokines and aryl hydrocarbon receptor signalling in rat liver oval cells (2008-2009) | C. Dietrich JGU, Mainz, SRN | J. Vondráček, Institute of Biophysics, AS CR, Brno, Czech Republic | CzechRepublic, Germany |
27 | KONTAKT (Czech-Slovak research collaboration)
| Effect of COX-2 inhibition in tumor and non-tumor colon epithelial cells exposed to phototoxic effect of hypericin | A.Kozubík, , Institute of Biophysics, AS CR, Brno, Czech Republic P. Fedoročko | A.Kozubík, Institute of Biophysics, AS CR, Brno, Czech Republic | CzechRepublic, SK |
28 | KONTAKT (Czech-Hungarian research collaboration)
| Role of lipid rafts in regulation of cell signalling leading to modulation of cytokinetics of cancer cells
| A.Kozubík, Institute of Biophysics, AS CR, Brno, Czech Republic | A.Kozubík, Institute of Biophysics, AS CR, Brno, Czech Republic | CzechRepublic, Hungary |
29 | Philip Morris External Research Program | Modulation of Acute Pulmonary Inflammatory Responses by Myeloperoxidase | L. Kubala, Institute of Biophysics, AS CR, Brno, Czech Republic | L. Kubala, Institute of Biophysics, AS CR, Brno, Czech Republic | Czech Republic, USA |
30 | KONTAKT (Czech-Slovak research collaboration) | The effects of blood platelets on the oxidative burst of neutrophils | A. Lojek, Institute of Biophysics, AS CR, Brno, Czech Republic | A. Lojek, Institute of Biophysics, AS CR, Brno, Czech Republic | CzechRepublic, SK |
31 | KONTAKT (Czech-Slovak research collaboration) | Antioxidant and antiphagocytic properties of chemical and natural substances and drugs | A. Lojek, Institute of Biophysics, AS CR, Brno, Czech Republic | A. Lojek, Institute of Biophysics, AS CR, Brno, Czech Republic | CzechRepublic, SK |
32 | KONTAKT (Czech-Slovak research collaboration) | The role of platelets, neutrophils and components of extracellular matrix in inflammation | A. Lojek, Institute of Biophysics, AS CR, Brno, Czech Republic | A. Lojek, Institute of Biophysics, AS CR, Brno, Czech Republic | CzechRepublic, SK |
33 | KONTAKT (Czech-Hungarian research collaboration) | Changes in granulocyte functions following severe tissue injury | A. Lojek, Institute of Biophysics, AS CR, Brno, Czech Republic | A. Lojek, Institute of Biophysics, AS CR, Brno, Czech Republic | CzechRepublic, Hungary |
36 | KONTAKT (Czech-Hungarian research collaboration) | Effect of ischemic preconditioning on reperfusion injury | A. Lojek, Institute of Biophysics, AS CR, Brno, Czech Republic | A. Lojek, Institute of Biophysics, AS CR, Brno, Czech Republic | CzechRepublic, Hungary |
37 | NATO CBP | Collagen, platelet and neutrophil interactions with respect to wound healing | M. Číž, Institute of Biophysics, AS CR, Brno, Czech Republic | M. Číž, Institute of Biophysics, AS CR, Brno, Czech Republic | CzechRepublic, Bulgaria |
38 | AV CR – DAAD | Trombocytes, an extra-leukocyte pool for Myeloperoxidase | L. Kubala, Institute of Biophysics, AS CR, Brno, Czech Republic | L. Kubala, Institute of Biophysics, AS CR, Brno, Czech Republic | Czech Republic, Germany |
39 | International research project Czech Republic – Germany | Role of myeloperoxidase in the regulation of platelets physiology | L. Kubala, Institute of Biophysics, AS CR, Brno, Czech Republic | L. Kubala, Institute of Biophysics, AS CR, Brno, Czech Republic | Czech Republic, Germany |
40 | COST – European Cooperation in Science and Technology | Lipid peroxidation associated disorders | A. Lojek, Institute of Biophysics, AS CR, Brno, Czech Republic | A. Lojek, Institute of Biophysics, AS CR, Brno, Czech Republic | Czech Republic, European Union |
41 | Wellcome Trust International Senior Research Fellowship | Structure, dynamics, molecular interactions and thermodynamics of DNA and RNA: advanced computational studies | Jiří Šponer, Institute of Biophysics, AS CR, Brno, Czech Republic | Jiří Šponer, Institute of Biophysics, AS CR, Brno, Czech Republic | United Kingdom, Czech Republic |
42 | International research project Czech Republic – Switzerland | Genus Silene as a model for mating systems and adaptation mechanisms evolution – from ecology to genomics
| Dr. Roman Hobza, Institute of Biophysics, Brno, CR | Prof. Alex Widmer, Department of Integrative Biology, University of Zurich, Switzerland | Switzerland, Czech Republic |
43 | International research project Czech Republic - Spain | Structure and evolution of sex chromosomes in the dioecious plant models
| Prof. Boris Vyskot, Laboratory of Plant Developmental Genetics, Institute of Biophysics, Brno, CR | Prof. Manuel Quesada Jamilena, Department of Applied Biology, University of Almería, Spain | Spain, Czech Republic |
44 | Academy of Sciences of the Czech Republic, international cooperation | Complex interaction of oncology-related important transcription factors with target DNA in vitro and in vivo (2009-2012) | Václav Brázda, Ph.D., Institute of Biophysics ASCR, v.v.i. | Cheryl Arrowsmith, Ph.D., Ontario Cancer Institute, Toronto, Canada | Czech Republic, Canada |