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Publications
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STING Agonist-Mediated Cytokine Secretion Is Accompanied by Monocyte Apoptosis
ACS Infectious Diseases 8 (3): 463–471 (2022)
The cGAS-STING (cyclic GMP-AMP synthase–stimulator of interferon genes) pathway plays a crucial role in inducing an antiviral and antitumor immune response. We studied the effects of synthetic STING agonists on several immune populations and related cytokine production. In comparison with the toll-like receptor 7 (TLR7) agonist, STING agonists induced secretion of a broader proinflammatory cytokine spectrum. Unlike the TLR7 agonist, the structurally diverse STING agonists partially depleted B and NK cells and completely depleted CD14+ monocytes via induction of apoptosis. The TANK-binding kinase 1 inhibitor efficiently prevented interferon alpha (IFNα) secretion and cell depletion, suggesting their possible dependence on the cGAS-STING pathway activation. Finally, IFNα, tumor necrosis factor alpha, interleukin 6, and interleukin 1 beta secretion and CD14+ monocyte apoptosis were primary responses to STING agonists, whereas IFNγ was secreted secondarily. These findings bring new…
Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases
Journal of Medicinal Chemistry 65 (5): 4030–4057 (2022)
Visualization of Sentinel Lymph Nodes with Mannosylated Fluorescent Nanodiamonds
Advanced Functional Materials 2022: Early View
Optimizing the chemiluminescence of a light-producing deoxyribozyme
ChemBioChem 2022: Early View