Our research focuses on the cellular and molecular mechanisms of desensitization of hormone response mediated by the activation of G protein coupled receptors (GPCR). G protein coupled receptors are plasma membrane integral proteins which serve as transducers of extracellular signals across the plasma membrane bilayer to the cell interior. GPCR play a key role in the regulation of many physiological processes and functions. Moreover, GPCRs represent one of the most important groups of targets for therapeutics.
The main areas of the research are:
- The role of cell membrane and membrane domains
- Opioid receptors and drug addiction
- The effect of monovalent ions on δ-opioid receptors – analysis of lithium effect in living cells and isolated cell membranes
- GABA-B - signalling cascades
BACK
-
Projects
-
Publications
-
Photogallery
Cell (plasma) membrane (PM) serves as a protective barrier, but also plays a role in the cellular communication. The integrity of hydrophobic lipid environment of PM is an important factor affecting…
More
Addiction to opioid drugs (opioids) represents one of the most severe forms of drug abuse. Opium is one of the oldest known drugs and is used for its medicinal and euphoric effects for thousands of…
More
Activity of opioid receptor (OR) is among others modulates by monovalent cations especially by sodium (Na+) and lithium (Li+) which atomic radius is very similar to those of sodium. Lithium is used…
More
Metabotropic receptors for gamma-aminobutyric acid (GABA-B-R) play a crucial role in the regulation of synaptic transmission in the central nervous system (CNS). We study the ability of GABA-B-R to…
More
Transient receptor potential (TRP) channels are a wide family of non-selective ion channels responsible for monovalent and divalent cation influx into the cells. Members of this family are involved…
More
2016
Vošahlíková, Miroslava - Svoboda, Petr. Lithium - therapeutic tool endowed with multiple beneficiary effects caused by multiple mechanisms. Acta Neurobiologiae Experimentalis. 2016, roč.76, 1,…
More
2014
Vošahlíková, Miroslava - Jurkiewicz, Piotr - Roubalová, Lenka - Hof, Martin - Svoboda, Petr . High- and low-affinity sites for sodium in delta-OR-G(i)1 alpha (Cys(351)-Ile(351)) fusion protein…
More
2010
Bouřová, Lenka - Vošahlíková, Miroslava - Kagan, D. - Dlouhá, Kateřina - Novotný, J. - Svoboda, Petr . Long-term adaptation to high doses of morphine causes desensitization of micro-OR- and…
More