CS

Jiří Brynda

mail jiri.bryndainvalid-email-name@invalid-email-domainuochb.cas.cz
phone +420 220 183 210
Scientist
Pavlína Maloy Řezáčová Group
Structural Biology
All publications

Latest publications

Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes
J. Benýšek M. Buša P. Rubešová J. Fanfrlík M. Lepšík J. Brynda Z. Matoušková U. Bartz M. Horn M. Gütschow M. Mareš
Journal of Enzyme Inhibition and Medicinal Chemistry 37 (1): 515-526 (2022)
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Structure-activity relationship and biochemical evaluation of novel fibroblast activation protein and prolyl endopeptidase inhibitors with α-ketoamide warheads
A. Šimková T. Ormsby N. Sidej L. Poštová Slavětínská J. Brynda J. Beranová P. Šácha P. Majer J. Konvalinka
European Journal of Medicinal Chemistry 224: 113717 (2021)
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Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors
R. Reiberger K. Radilová M. Král V. Zima P. Majer J. Brynda M. Dračínský J. Konvalinka M. Kožíšek A. Machara
International Journal of Molecular Sciences 22 (14): 7735 (2021)
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Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery
R. Kryštůfek P. Šácha J. Starková J. Brynda M. Hradilek E. Tloušťová J. Grzymska W. Rut M. J. Boucher M. Drag P. Majer M. Hájek P. Řezáčová H. D. Madhani C. S. Craik J. Konvalinka
Journal of Medicinal Chemistry 64 (10): 6706–6719 (2021)
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