Richard R. Schrock

"Third generation" M(NR)(CHCMe₂R')(OR)(Pyr) (MonoAlkoxidePyrrolide or MAP) species, isolated or prepared in situ, can be remarkably active and efficient metathesis catalysts.¹ MAP species have characteristics that make them unique for many metathesis reactions, among them Z- and enantioselective ring-opening/cross-metatheses, Z-selective ROMP to give cis,syndiotactic polymers, ethenolysis of internal olefins such as oleates, Z-selective coupling of terminal olefins, Z-selective cross coupling of terminal olefins. Z-selective syntheses of large rings such as Epothilone C and Nakadomarin A, and Z-selective ethenolysis of E/Z mixtures to give pure E isomers.

1. a) Schrock, R. R.; Hoveyda, A. H. Angew. Chem. Int. Ed. 2003, 42, 4592. b) Schrock, R. R. Chem. Rev. 2002, 102, 145. c) Schrock, R. R. Angew. Chem. Int. Ed. 2006, 45, 3748. d) Schrock, R. R. Chem. Rev. 2009, 109, 3211. e) Malcolmson, S. J.; Meek, S. J.; Sattely, E. S.; Schrock, R. R.; Hoveyda, A. H. Nature 2008, 456, 933. f) Sattely, E. S.; Meek, S. J.; Malcolmson, S. J.; Schrock, R.R.; Hoveyda, A. H. J. Am. Chem. Soc. 2009, 131, 943. g) Yu, M.; Wang, C.; Kyle, A. F.; Jakubec, P.; Dixon, D. J.; Schrock, R. R.; Hoveyda, A. H. Nature 2011, 479, 88.