Fig: Feeding aligned with activity status (as occurs in rats under ad libitum conditions) is associated with coupling between the peaks in insulin and corticosterone levels and the phases of the clocks in the endocrine and exocrine parts of the pancreas.
doi:10.1007/s00018-022-04354-7. Misaligned meals become a frequent lifestyle transgression related to current societal pressure imposed on behavior.
Here we provide the first evidence in rats and mice that whereas the clock in the endocrine pancreas shifts according to mealtime, the clock in the exocrine pancreas can be severely impaired by incorrect meal timing. Our findings pave a new avenue for future investigation of the relationship between long-term circadian misalignment and a higher risk of development of metabolic disorders.
