Nature

Alzheimer’s drug slows mental decline in trial — but is it a breakthrough?

Researchers are cautiously optimistic following companies’ announcement of positive results for lecanemab.

What do Nord Stream methane leaks mean for climate change?

Researchers are rushing to calculate the greenhouse-gas emissions resulting from mysterious leaks in major gas pipelines that connect Russia to Europe.

Katharine Sanderson
News 30 Sept 2022
Why scientists fear monkeypox spreading in wild animals

Monkeypox rampant in wildlife would make the virus impossible to control, warn scientists.

Emiliano Rodríguez Mega
News 30 Sept 2022
The oldest complete jawed vertebrates from the early Silurian of China

Two new species of well-preserved jawed fishes with complete bodies from the early Silurian period (Telychian age, around 436 million years ago) of Chongqing, South China are described: a jawed stem gnathostome, Xiushanosteus mirabilis, and a chondrichthyan, Shenacanthus vermiformis.

You-an Zhu
Qiang Li
Min Zhu
Article 28 Sept 2022
Daily briefing: Psychedelics shed light on the underpinnings of consciousness

People are getting their brains scanned after taking psychedelic drugs. Plus, how COVID lockdowns changed bird behaviour, and the calibration of the Webb space telescope has caused “a little bit of panic”.

Flora Graham
Nature Briefing 29 Sept 2022
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Current Issue 29 Sept 2022

News & Comment

Genes’ effect on lifespan depends on sex and age, mouse study finds

In a large study, researchers identified several areas of the mouse genome that influence longevity.

Liam Drew

News 30 Sept 2022
Floods, fires and fluorescent fish — September’s best science images
Emma Stoye
News 30 Sept 2022
What Italy’s far-right election victory means for science
Giorgia Guglielmi
News 30 Sept 2022
Why scientists fear monkeypox spreading in wild animals
Emiliano Rodríguez Mega
News 30 Sept 2022
What do Nord Stream methane leaks mean for climate change?
Katharine Sanderson
News 30 Sept 2022
Do fungi lurking inside cancers speed their growth?
Max Kozlov
News 29 Sept 2022
Where is the UK science minister? Government’s plans worry researchers
Sarah Wild
News 29 Sept 2022

Latest Reviews & Analysis

- Narrow hiring practices at US universities revealed
  
  An analysis of faculty members employed at academic institutions in the United States reveals that most employees were trained at just a few universities. The finding provides insights into how hiring perpetuates inequalities.
  
  Cassidy R. Sugimoto
  
  News & Views 29 Sept 2022
- Machine assembly of carbohydrates with more than 1,000 sugar units
  
  Efforts to probe the biological functions of carbohydrates have long been limited by the lack of such molecules with well-defined structures. An automated carbohydrate synthesizer has been developed that could remedy this.
  Hanchao Cheng
  Peng George Wang
  
  News & Views 29 Sept 2022
- A nomenclature consensus for nervous system organoids and assembloids
  
  The nomenclature for human multicellular models of nervous system development and disease, including organoids, assembloids and transplants, is discussed and a consensus framework is presented.
  Sergiu P. Pașca
  Paola Arlotta
  Flora M. Vaccarino
  
  Perspective 28 Sept 2022
- Outer regions of galaxy clusters host radio megahaloes
  
  Observations reveal the presence of large volumes of ionized gas surrounding four galaxy clusters. The properties of these ‘megahaloes’ are distinct from those of similar haloes near the clusters, implying different formation mechanisms.
  Kenda Knowles
  
  News & Views 28 Sept 2022
- Innovative chemistry yields potential antidepressant drugs
  
  Computational simulation of interactions of each of 75 million molecules with a model structure of the 5-HT_2A receptor, which mediates the actions of psychedelic drugs, identified molecules that selectively activate the receptor. When tested in mice, two of these compounds had antidepressant-like actions without the side effects of psychedelic drugs.
  
  Research Briefing 28 Sept 2022
- Fossils reveal the deep roots of jawed vertebrates
  Matt Friedman
  
  News & Views 28 Sept 2022
- From the archive: ancient poisonous honey, and museum photography
  
  News & Views 27 Sept 2022
- Hybrid laser-trapping technique lights the way for neutral atoms
  Giulia Semeghini
  
  News & Views 26 Sept 2022
- Structure of wheat immune receptor helps guide design of disease-resistant varieties
  
  Research Briefing 26 Sept 2022

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Latest Research articles

Stroke genetics informs drug discovery and risk prediction across ancestries

A cross-ancestry meta-analysis of genome-wide association studies identifies association signals for stroke and its subtypes at 89 (61 new) independent loci, reveals putative causal genes, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as potential drug targets, and provides cross-ancestry integrative risk prediction.

Aniket Mishra
Rainer Malik
Stephanie Debette
Article Open Access 30 Sept 2022
Viruses inhibit TIR gcADPR signaling to overcome bacterial defense

Azita Leavitt
Erez Yirmiya
Rotem Sorek
Article 29 Sept 2022
Prenatal immune stress blunts microglia reactivity, impairing neurocircuitry

Aberrantly formed microglia due to an adverse prenatal environment affect long-term microglia reactivity and proper striatal circuit development in mice

Lindsay N. Hayes
Kyongman An
Akira Sawa
Article 28 Sept 2022
The oldest gnathostome teeth

Direct evidence for the presence of jawed vertebrates in the early Silurian (around 439 million years ago) is provided by isolated tooth whorls of the gnathostome Qianodus duplicis from Guizhou province, China.

Plamen S. Andreev
Ivan J. Sansom
Min Zhu
Article 28 Sept 2022
LRRC15⁺ myofibroblasts dictate the stromal setpoint to suppress tumour immunity

LRRC15-positive cancer-associated fibroblasts constitute a pivotal axis in tumorigenesis and are potential therapeutic targets to improve responses to immune checkpoint blockade.

Akshay T. Krishnamurty
Justin A. Shyer
Shannon J. Turley
Article Open Access 28 Sept 2022