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Cycloiridated Helicenes as Chiral Catalysts in the Asymmetric Transfer Hydrogenation of Imines
ACS Catalysis 12 (17): 10793–10800 (2022)
The asymmetric synthesis of optically pure and conformationally locked oxabenzo[5]helicenes bearing pyridin-2-yl or isoquinolin-3-yl substituents and their transformation into the corresponding cycloiridated organometallics are described. These helically chiral Cp*IrIII(X)C,N-complexes (X = Cl, I) also contain a configurationally unstable pseudotetrahedral iridium center. This center undergoes epimerization at room temperature, and its relative stereochemistry, especially in the solid state, depends on the nature of the coordinated ligands. Cycloiridated helicenes were used in the asymmetric transfer hydrogenation of prochiral aromatic imines with formic acid/triethylamine to reach up to 96:4 er. It is assumed that the chirality transfer is controlled by the auxiliary helix rather than the IrIII stereogenic center of the chiral iridacycles.
A multifaceted strategy to improve recombinant expression and structural characterisation of a Trypanosoma invariant surface protein
Scientific Reports 12: 12706 (2022)
Silicon-bridged (1→1)-disaccharides: an umpoled glycomimetic scaffold
Organic and Biomolecular Chemistry 2022: Early View
Selectivity of Oxidizing Agents toward Axial and Equatorial Hydroxyl Groups
Journal of Organic Chemistry 87 (14): 9157–9170 (2022)
Honeybee Iflaviruses Pack Specific tRNA Fragments from Host Cells in Their Virions
ChemBioChem 2022: Early View