Optical Biosensors

Focus

The team is engaged in the research of photonic and plasmonic (nano) structures and functional biomolecular files, the development of optical measuring methods and systems, the study of biomolecular interactions and detection of chemical and biological agents in areas such as medical diagnostics, food quality control or environmental monitoring.

Research projects

• Multifunctional nanostructures for plasmonic sensing of biomolecules related to oncohematological diseases
• Novel biophotonic tools for investigation of cellular processes
• Advanced plasmonic biosensors: towards the next-generation biomolecular interaction analysis

Complete overview of research projects

Publications

1. J. Slabý, J. Homola, Performance of label-free optical biosensors: What is figure of merit (not) telling us?, Biosensors and Bioelectronics, Volume 212, 114426 (2022). 
2. Y. Wang, A. Kálosi, Y. Halahovets, I. Romanenko, J. Slabý, J. Homola, J. Svoboda, A. de los Santos Pereira, O. Pop-Georgievski, Grafting density and antifouling properties of poly[N-(2-hydroxypropyl) methacrylamide] brushes prepared by “grafting to” and “grafting from”, Polymer Chemistry 13, 3815-3826 (2022). 
3. H. Altug, SH. Oh, S.A. Maier, J. Homola: Advances and applications of nanophotonic biosensors. Nat. Nanotechnol. 17, 5–16 (2022).
4. T.  Špringer, Z. Krejčík, J. Homola: Detecting attomolar concentrations of microRNA related to myelodysplastic syndromes in blood plasma using a novel sandwich assay with nanoparticle release, Biosensors and Bioelectronics 194, 113613 (2021). 
5. A. Ligasová, I. Rosenberg, M. Bocková, J. Homola, K. Koberna: Anchored linear oligonucleotides: the effective tool for the real-time measurement of uracil DNA glycosylase activity, Open Biol. 11, 210136 (2021).

Complete overview of publications