Fig. Maternal signals drive rhythmicity in the fetal suprachiasmatic nuclei before their molecular clock develops.
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Fig. Maternal signals drive rhythmicity in the fetal suprachiasmatic nuclei before their molecular clock develops.
doi:10.1371/journal.pbio.3001637.g005. Our results indicate the importance of a well-functioning maternal biological clock in providing rhythmic environment during the fetal brain development.
During development in of the fetal suprachiasmatic nuclei, maternal stimuli may substitute for an absent inter-cellular web of synapses and drive cell-population rhythms before the SCN clock fully matures. Distinct maternal signals rhythmically control a variety of neuronal processes in the fetal rat suprachiasmatic nuclei before they begin to operate as the central circadian clock.