CS

Institute of Organic Chemistry
and Biochemistry of the CAS

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IOCB Prague celebrates yet another ERC Advanced grant
IOCB Prague celebrates yet another ERC Advanced grant
30 March 2023
The Institute of Organic Chemistry and Biochemistry (IOCB Prague) of the Czech Academy of Sciences adds another great success to its portfolio. The European Research Council has…
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A breakthrough in big data processing helps trace chemicals in complex mixtures
A breakthrough in big data processing helps trace chemicals in complex mixtures
8 March 2023
An international team of scientists led by Tomáš Pluskal from the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) has introduced a…
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The mechanism of virus-attachment blockers on DC-SIGN
The mechanism of virus-attachment blockers on DC-SIGN
22 March 2023
A new study from Martin Lepšík from IOCB Prague as one of the first authors provides a detailed understanding of interactions between multivalent virus-attachment blockers and DC…
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Event calendar

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4
MAY
Invited Lecture – Lisa Stowers
4 May 2023, IOCB Prague
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16
MAY
Dana Hocková Lecture: Štěpánka Vaňáčová
16 May 2023, IOCB Prague
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19
JUL
International Symposium CURO-π5
19 July — 21 July 2023, Hermitage Hotel…
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Take the step towards a career in organic chemistry and biochemistry...
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Publications

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Integrative analysis of multimodal mass spectrometry data in MZmine 3
Integrative analysis of multimodal mass spectrometry data in MZmine 3
R. Schmid S. Heuckeroth A. Korf A. Smirnov O. Myers T. S. Dyrlund R. Bushuiev K. J. Murray N. Hoffmann M. Lu A. Sarvepalli Z. Zhang M. Fleischauer K. Dührkop M. Wesner S. J. Hoogstra E. Rudt O. Mokshyna C. Brungs K. Ponomarov L. Mutabdžija T. Damiani C. J. Pudney M. Earll P. O. Helmer T. Fallon T. Schulze A. Rivas-Ubach A. Bilbao H. Richter L. Nothias M. Wang M. Orešič J. Weng S. Böcker A. Jeibmann H. Jeibmann U. Karst P. E. Dorrestein D. Petras X. Du T. Pluskal
Nature Biotechnology 2023: Early View
Innovation in mass spectrometry (MS) and the rapidly increasing throughput and sensitivity of MS instrumentation require adaptations and innovations in data processing tools. Here, we introduce MZmine 3, a scalable MS data analysis platform that supports hybrid datasets from various instrumental setups, including liquid and gas chromatography (LC and GC)–MS, ion mobility spectrometry (IMS)–MS and MS imaging. In particular, the integration of IMS–MS imaging and LC–IMS–MS datasets provides opportunities for spatial metabolomics analyses with increased annotation confidence.
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Gas Dynamic Virtual Nozzle Sprayer for an Introduction of Liquid Samples in Atmospheric Pressure Ionization Mass Spectrometry
B. Kloudová T. Strmeň V. Vrkoslav Z. Chára O. Pačes J. Cvačka
Analytical Chemistry 95 (8): 4196–4203 (2023)
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Surfactant Proteins SP-B and SP-C in Pulmonary Surfactant Monolayers: Physical Properties Controlled by Specific Protein–Lipid Interactions
J. Liekkinen A. Olżyńska L. Cwiklik J. Bernardino de la Serna I. Vattulainen M. A. Javanainen
Langmuir 2023: Early View
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