The Laboratory of Experimental Hypertension is studying the mechanisms of blood pressure regulation and end-organ damage in rats with different types of experimental hypertension.
Our research is focused mainly on:
- Cardiovascular effects of new antidiabetics – gliflozins in model of experimental hypertension and chronic heart failure
- Central and peripheral mechanisms of blood pressure regulation
- Role of sympathetic and parasympathetic nervous system in cardiovascular diseases
- Cardiovascular effects of new analogs of neuropeptides regulating food intake in rats and their relation to neuroprotection in Alzheimer disease (cooperation with IOCHB CAS).
Projects
Achievements
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Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague) in collaboration with Institute of Physiology of the CAS developed new compounds with positive effects in experimental animal models of obesity and type II diabetes.
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Publications
Zicha; Josef - Řezáčová; Lenka - Behuliak; Michal - Vaněčková; Ivana
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Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension
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Physiological Research. 2022; 71(6); 763-770
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IF = 2.139
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Řezáčová; Lenka - Vaněčková; Ivana - Hojná; Silvie - Vavřínová; Anna - Valovič; Pavol - Rauchová; Hana - Behuliak; Michal - Zicha; Josef
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Both central sympathoexcitation and peripheral angiotensin II-dependent vasoconstriction contribute to hypertension development in immature heterozygous Ren-2 transgenic rats
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Hypertension Research. 2022; 45(3); 414-423
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IF = 5.528
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Pačesová; A. - Holubová; M. - Hrubá; L. - Strnadová; V. - Neprašová; B. - Pelantová; H. - Kuzma; M. - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Age-related metabolic and neurodegenerative changes in SAMP8 mice
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Aging. 2022; 14(18); 7300-7327
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IF = 5.955
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Mráziková; L. - Hojná; Silvie - Pačesová; A. - Hrubá; L. - Strnadová; V. - Neprašová; Barbora - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Palmitoylated prolactin-releasing peptide treatment had neuroprotective but not anti-obesity effect in fa/fa rats with leptin signaling disturbances
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Nutrition & Diabetes. 2022; 12(1)); 26
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IF = 4.725
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Malínská; H. - Hüttl; M. - Marková; I. - Miklánková; D. - Hojná; Silvie - Papoušek; František - Šilhavý; Jan - Mlejnek; Petr - Zicha; Josef - Hrdlička; Jaroslav - Pravenec; Michal - Vaněčková; Ivana
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Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein
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Biomedicines. 2022; 10(9)); 2066
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IF = 4.757
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Overview of alterations in calcium sensitization during development of spontaneously hypertension in the rat The schematic representation of possible regulatory mechanisms involved in RhoA/Rho kinase pathway is demonstrated in normotensive (a), prehypertensive (b) and hypertensive (c) rats.
Recording of contraction of isolated femoral artery stimulated by norepinephrine (NE).
Aorta section – α-actin (red), nuclei (blue) and autofluorescence (green).
Adrenal section stained for tyrosine hydroxylase (detected by Vectastain ABC kit).
Recording of blood pressure.