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+ endocannabinoids, + cannabinoid receptor, + receptors coupled to G-proteins
We have found that SGIP1 (SH3 domain GRB2-like endophilin-interacting protein 1) modifies the CB1R signalling pathway by interfering with internalization that follows CB1R activation. We also found that SGIP1, like CB1R, concentrates in presynaptic portions of neurons. [pubmed] [doi]
We have tested SGIP1 knockout mice in a battery of behavioural tests. The SGIP1−/− mice did not show changes in sensorimotor gating, exploratory levels, or working memory, but showed decreased anxiety-like symptoms. Our results suggest that the absence of SGIP1 leads to changes in certain behaviours induced by THC administration and CB1R activation. [pubmed] [doi]
We have found that SGIP1-/- mice are more sensitive to analgesics. Our results suggest that SGIP1 is involved in the regulation of emotionality, mood, and nociception and modulates in vivo signalling of CB1 cannabinoid receptors. [pubmed] [doi]