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Laboratory of Experimental Hypertension

Laboratory of Experimental Hypertension

The Laboratory of Experimental Hypertension is studying the mechanisms of blood pressure  regulation and end-organ damage in rats with different types of experimental hypertension.

Our research is focused mainly on:

  • Cardiovascular effects of new antidiabetics – gliflozins in  model of experimental hypertension and chronic heart failure
  • Central and peripheral mechanisms of blood pressure regulation
  • Role of sympathetic and parasympathetic nervous system  in cardiovascular diseases
  • Cardiovascular effects  of new analogs of neuropeptides regulating food intake in rats and their relation to neuroprotection in Alzheimer disease (cooperation with IOCHB CAS).

Projects

Achievements

Publications

Mráziková; L. - Hojná; Silvie - Vaculová; P. - Strnad; Š. - Vrkoslav; V. - Pelantová; H. - Kuzma; M. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Lipidized PrRP Analog Exhibits Strong Anti-Obesity and Antidiabetic Properties in Old WKY Rats with Obesity and Glucose Intolerance . Nutrients. 2023; 15(2)); 280 . IF = 6.706 [ASEP] [ doi ]
Kala; P. - Vaňourková; Z. - Škaroupková; P. - Kompanowska - Jezierska; E. - Sadowski; J. - Walkowska; A. - Veselka; J. - Táborský; M. - Maxová; H. - Vaněčková; Ivana - Červenka; L. Endothelin type A receptor blockade increases renoprotection in congestive heart failure combined with chronic kidney disease: Studies in 5/6 nephrectomized rats with aorto-caval fistula . Biomedicine & Pharmacotherapy. 2023; 158(February)); 114157 . IF = 7.419 [ASEP] [ doi ]
Kala; P. - Gawrys; O. - Miklovic; M. - Vaňourková; Z. - Škaroupková; P. - Jíchová; Š. - Sadowski; J. - Kompanowska - Jezierska; E. - Walkowska; A. - Veselka; J. - Táborský; M. - Maxová; H. - Vaněčková; Ivana - Červenka; L. Endothelin type A receptor blockade attenuates aorto-caval fistula-induced heart failure in rats with angiotensin II-dependent hypertension . Journal of Hypertension. 2023; 41(1); 99-114 . IF = 4.776 [ASEP] [ doi ]
Zicha; Josef - Řezáčová; Lenka - Behuliak; Michal - Vaněčková; Ivana . Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension . Physiological Research. 2022; 71(6); 763-770 . IF = 2.139 [ASEP] [ doi ]
Řezáčová; Lenka - Vaněčková; Ivana - Hojná; Silvie - Vavřínová; Anna - Valovič; Pavol - Rauchová; Hana - Behuliak; Michal - Zicha; Josef . Both central sympathoexcitation and peripheral angiotensin II-dependent vasoconstriction contribute to hypertension development in immature heterozygous Ren-2 transgenic rats . Hypertension Research. 2022; 45(3); 414-423 . IF = 5.528 [ASEP] [ doi ]
Pačesová; A. - Holubová; M. - Hrubá; L. - Strnadová; V. - Neprašová; B. - Pelantová; H. - Kuzma; M. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Age-related metabolic and neurodegenerative changes in SAMP8 mice . Aging. 2022; 14(18); 7300-7327 . IF = 5.955 [ASEP] [ doi ]
Mráziková; L. - Hojná; Silvie - Pačesová; A. - Hrubá; L. - Strnadová; V. - Neprašová; Barbora - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Palmitoylated prolactin-releasing peptide treatment had neuroprotective but not anti-obesity effect in fa/fa rats with leptin signaling disturbances . Nutrition & Diabetes. 2022; 12(1)); 26 . IF = 4.725 [ASEP] [ doi ]
Malínská; H. - Hüttl; M. - Marková; I. - Miklánková; D. - Hojná; Silvie - Papoušek; František - Šilhavý; Jan - Mlejnek; Petr - Zicha; Josef - Hrdlička; Jaroslav - Pravenec; Michal - Vaněčková; Ivana . Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein . Biomedicines. 2022; 10(9)); 2066 . IF = 4.757 [ASEP] [ doi ]
Chao; YM. - Rauchová; Hana - Chan; J. Y. H. Disparate Roles of Oxidative Stress in Rostral Ventrolateral Medulla in Age-Dependent Susceptibility to Hypertension Induced by Systemic l-NAME Treatment in Rats . Biomedicines. 2022; 10(9)); 2232 . IF = 4.757 [ASEP] [ doi ]
Holá; L. - Železná; B. - Karnošová; A. - Kuneš; Jaroslav - Fehrentz; J. A. - Denoyelle; S. - Cantel; S. - Blechová; M. - Sýkora; D. - Myšková; A. - Maletínská; L. A Novel Truncated Liver Enriched Antimicrobial Peptide-2 Palmitoylated at its N-Terminal Antagonizes Effects of Ghrelin . Journal of Pharmacology and Experimental Therapeutics. 2022; 383(2); 129-136 . IF = 4.404 [ASEP] [ doi ]

Article photogallery

Přehled změn vápníkové sensitizace za vývoje spontánní hypertenze potkana Schéma možných regulačních mechanismů účastnících se RhoA/Rho kinázové dráhy, které byly zjištěny u normotenzních (a), prehypertenzních (b) a hypertenzních (c) potkanů. Overview of alterations in calcium sensitization during development of spontaneously hypertension in the rat The schematic representation of possible regulatory mechanisms involved in RhoA/Rho kinase pathway is demonstrated in normotensive (a), prehypertensive (b) and hypertensive (c) rats.
Průběh záznamu kontrakce izolované femorální artérie vyvolané noradrenalinem (NE, norepinefrin). Recording of contraction of isolated femoral artery stimulated by norepinephrine (NE).
Řez aortou – značený je α-aktin (červený), jádra (modrá) a zelený signál představuje autofluorescenci. Aorta section – α-actin (red), nuclei (blue) and autofluorescence (green).
The entire photogallery

People

     RNDr. Ivana Vaněčková, DSc.
Head of the Laboratory
MUDr. Josef Zicha, DrSc.
Deputy Head of the Laboratory
RNDr. Jaroslav Kuneš, DrSc.
Senior Researcher
MUDr. Hana Rauchová, CSc.
Senior Researcher
  RNDr. Milada Dobiášová, DrSc.
Senior Researcher
Mgr. Michal Behuliak, Ph.D.
Senior Researcher
Ing. Michaela Kadlecová, Ph.D.
Research Assistant
Mgr. Silvie Hojná, Ph.D.
Research Assistant
RNDr. Lenka Řezáčová, Ph.D.
Research Assistant
Bc. Martina Sabolová
Pregradual student
Alena Charvátová
Technician
Zdeňka Kopecká
Technician

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