Research and Measurement of Signals Generated by Nanostructures

Sponsor: Czech Science Foundation

Co-principal investigator: Jiří Pokorný, DrSc.

Members: Daniel Havelka, MSc.; František Jelínek, Ph.D.; Ondřej Kučera, Ph.D.; Fedor Šrobár, DSc.

From: 2011-01-01

To: 2013-12-31

Based on analysis of artificial and biological structures, a unique screened extremely sensitive system affording acquisition of signal irradiated by described nanostructures will be built. Requested solution is a sensor with linear surface area dimensions 100 nm or less, with signal power level below 0.1 fW, and discrete frequencies in the 0-20 MHz and 10-50 GHz regions. The system would employ measured object positioning under microscope by micromanipulators and for data capture special sensors with preamplifiers transforming primary signals generated by nanostructures into a form suitable for input to subsequent macroscopic preamplifiers. Apparature will be used to measure signals generated by nanostructures: the results will be interpreted within the physical context of the given kind of nanostructure.

1. D. Havelka, M. Cifra, O. Kučera, J. Pokorný, and J. Vrba: High-frequency electric field and radiation characteristics of cellular microtubule network. Journal of Theoretical Biology, no. 286, pp. 31-40, 2011. doi:10.1016/j.jtbi.2011.07.007
2. J. Pokorný, C. Vedruccio, M. Cifra and O. Kučera: Cancer physics: diagnostics based on damped cellular elastoelectrical vibrations in microtubules. European Biophysics Journal, no. 40, pp. 747-759, 2011.doi:10.1007/s00249-011-0688-1
3. O. Kučera, M. Cifra and J. Pokorný: Technical aspects of measurement of cellular electromagnetic activity. European Biophysics Journal, vol. 39, no. 10, pp. 1465-1470, 2010, doi:10.1007/s00249-010-0597-8
4. D. Havelka, O. Kučera, M.A. Deriu and M. Cifra: Electro-acoustic behavior of the mitotic spindle: a semi-classical coarse-grained model. PLoS ONE, vol. 9, no. 1, 2014. doi: 10.1371/journal.pone.0086501
5. J. Pokorný, J. Pokorný and J. Kobilková: Postulates on Electromagnetic Activity in Biological Systems and Cancer. Integrative Biology, vol. 5, no. 12, pp. 1439-1446, 2013. doi: 10.1039/C3IB40166A
6. J. Pokorný: Physical aspects of biological activity and cancer. AIP Advances, no. 2, pp. 011207/1-011207/11, 2012. doi: 10.1063/1.3699057