Metabolic syndrome is defined as the co-occurrence of several risk factors for type 2 diabetes and cardiovascular disease: mainly obesity, insulin resistance, high triglyceride and LDL cholesterol levels, and hypertension. These risk factors are determined by many genes with small effects and their interactions with environmental factors. Genome-wide association studies have so far revealed only a small fraction of the heritability of complex pathophysiological traits in humans. Thus, analyses of animal models of human complex diseases may represent a useful alternative. The department's research is focused on the following projects:
- Uncovering genes regulating hemodynamic and metabolic traits in the SHR strain.
- Analysis of the mechanisms underlying the development of salt sensitive hypertension.
Projects
Publications
Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Marková; I. - Malínská; H. - Hüttl; M. - Kazdová; L. - Kazantsev; D. - Mancini; M. - Novotný; J. - Pravenec; Michal
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CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study
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PLoS ONE. 2023; 18(4)); e0283276
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IF = 3.7
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doi
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Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Malínská; H. - Marková; I. - Hüttl; M. - Miklánková; D. - Kazdová; L. - Vrbacký; Marek - Pecinová; Alena - Mráček; Tomáš - Pravenec; Michal
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Hypolipidemic Effects of Beetroot Juice in SHR-CRP and HHTg Rat Models of Metabolic Syndrome: Analysis of Hepatic Proteome
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Metabolites. 2023; 13(2)); 192
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IF = 4.1
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doi
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Kurtz; T. W. - Morris Jr.; R. C. - Pravenec; Michal - Lujan; H. L. - DiCarlo; S. E.
Hypertension in Primary Aldosteronism Is Initiated by Salt-Induced Increases in Vascular Resistance With Reductions in Cardiac Output
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Hypertension. 2023; 80(5); 1077-1091
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IF = 8.3
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doi
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Hüttl; M. - Marková; I. - Miklánková; D. - Zapletalová; I. - Kujal; P. - Šilhavý; Jan - Pravenec; Michal - Malínská; H.
Hypolipidemic and insulin sensitizing effects of salsalate beyond suppressing inflammation in a prediabetic rat model
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Frontiers in Pharmacology. 2023; 14(3 Apr)); 1117683
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IF = 5.6
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doi
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Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Liška; František - Kubovčiak; Jan - Sticová; E. - Pravenec; Michal
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Sodium Accumulation and Blood Capillary Rarefaction in the Skin Predispose Spontaneously Hypertensive Rats to Salt Sensitive Hypertension
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Biomedicines. 2022; 10(2)); 376
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IF = 4.7
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doi
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Senko; A. N. - Overall; R. W. - Šilhavý; Jan - Mlejnek; Petr - Malínská; H. - Hüttl; M. - Marková; I. - Fabel; K. S. - Lu; L. - Stuchlík; Aleš - Williams; R. W. - Pravenec; Michal - Kempermann; G.
Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose
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PLoS Genetics. 2022; 18(4)); e1009638
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IF = 4.5
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doi
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Marković; Aleksandra - Tauchmannová; Kateřina - Šimáková; Miroslava - Mlejnek; Petr - Kaplanová; Vilma - Pecina; Petr - Pecinová; Alena - Papoušek; František - Liška; František - Šilhavý; Jan - Mikešová; Jana - Neckář; Jan - Houštěk; Josef - Pravenec; Michal - Mráček; Tomáš
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Genetic Complementation of ATP Synthase Deficiency Due to Dysfunction of TMEM70 Assembly Factor in Rat
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Biomedicines. 2022; 10(2)); 276
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IF = 4.7
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doi
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Malínská; H. - Hüttl; M. - Marková; I. - Miklánková; D. - Hojná; Silvie - Papoušek; František - Šilhavý; Jan - Mlejnek; Petr - Zicha; Josef - Hrdlička; Jaroslav - Pravenec; Michal - Vaněčková; Ivana
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Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein
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Biomedicines. 2022; 10(9)); 2066
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IF = 4.7
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doi
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Lusk; R. - Hoffman; P.L. - Mahaffey; S. - Rosean; S. - Smith; H. - Šilhavý; Jan - Pravenec; Michal - Tabakoff; B. - Saba; L. M.
Beyond Genes: Inclusion of Alternative Splicing and Alternative Polyadenylation to Assess the Genetic Architecture of Predisposition to Voluntary Alcohol Consumption in Brain of the HXB/BXH Recombinant Inbred Rat Panel
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Frontiers in genetics. 2022; 13(Mar 15)); 821026
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IF = 3.7
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doi
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Kurtz; T. W. - Pravenec; Michal - DiCarlo; S. E.
Do conclusions drawn from spot urine sodium measurements agree with the conclusions drawn from the 24-h urine measurements?
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Journal of Hypertension. 2022; 40(11); 2316-2317
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IF = 4.9
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doi
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