CS

List of PhD projects in 2020

CHEM cluster

  • Synthesis and application of N-fluoroalkylated compounds (Petr Beier Group)
  • Synthesis and transformations of fluoroalkylated heterocycles (Petr Beier Group)
  • Hydrogel microparticles mimicking red blood cells (Petr Cígler Group)
  • Modular hydrogel microrobots (Petr Cígler Group)
  • New RNA modifications for regulation of translation (Michal Hocek Group)
  • Chemical or enzymatic labeling of epigenetic nucleobases in DNA (Michal Hocek Group)
  • Modified nucleoside triphosphates with unnatural nucleobases for enzymatic synthesis of modified DNA (Michal Hocek Group)
  • Chemical synthesis of hypermodified oligonucleotides and DNA (Michal Hocek Group)
  • Nucleotides bearing polar or charged functional groups for enzymatic synthesis of modified DNA (Michal Hocek Group)
  • Design and synthesis of novel heterocyclic compounds and evaluation of their biological properties (Zlatko Janeba Group)
  • Design and synthesis of novel photoswitches derived from bisazobenzenes (Zlatko Janeba Group)
  • Synthesis of novel types of nucleotide analogues as enzyme inhibitors of nucleotide metabolism with potential antiparasitic and antibacterial activity (Zlatko Janeba Group)
  • Surface-Mounted Molecular Motors (Jiří Kaleta Group)
  • Molecular Machines in Supramolecular Systems (Jiří Kaleta Group)
  • Inhibitors of viral methyltransferases (Radim Nencka Group)
  • Multifunctional chelators for imaging and therapy (Miloslav Polášek Group)
  • Development of systems for reversible electron transfer (Tomáš Slanina Group)
  • Development of methods for stabilization of organic radicals (Tomáš Slanina Group)
  • Nonplanar unconventional pi-electron systems (Ivo Starý Group)
  • Enantioselective catalysis under the control of helical chirality (Ivo Starý Group)
  • Investigating customised functional molecules by the state-of-the-art cryogenic scanning probe microscopy (Ivo Starý Group)
  • Development of chemical tools to study and manipulate biological processes in live cells (Milan Vrábel Group)

BIO cluster

  • Hijacking of human host factors by viruses (Evžen Bouřa Group)
  • Role, biogenesis, and biodegradation of new dinucleoside polyphosphate RNA caps in prokaryotes (Hana Cahová Group)
  • Chemical biology tools for drug development (Jan Konvalinka Group)
  • Transient nuclear protein-protein interaction networks (Pavlína Maloy Řezáčová Group)
  • Targeting hematological malignancies using fragment-based drug design (Pavlína Maloy Řezáčová Group)
  • Cathepsin proteases in biomedicine (Michael Mareš Group)
  • Development of machine learning algorithms for the prediction of terpene synthase activity (Tomáš Pluskal Group – starts in May 2020)
  • Elucidation and engineering of the biosynthetic pathways of unique diterpenoids (Tomáš Pluskal Group – starts in May 2020)
  • Metabolic engineering of novel kavalactones using yeast quiescent cells (Tomáš Pluskal Group – starts in May 2020)
  • Nanoparticles for elimination of viruses spreading through air, water and bodily fluids (Virology – Jan Weber)

PHYS cluster

  • Spectroscopic Studies of Protein Fibrils (Petr Bouř Group)
  • Computational modeling of molecular optical activity (Petr Bouř Group)
  • Lanthanide Circularly Polarized Luminescence Probes of DNA Structure (Petr Bouř Group)
  • Application of metallo-DNA in nanoelectronics (Petr Bouř Group)
  • Spectroscopic studies of sugar-lectin interactions (Petr Bouř Group)
  • Exploring the fundamental molecular interactions modulating glycocalyx bioactivity (Pavel Jungwirth Group)
  • Liquid nebulization in ion sources for mass spectrometry (Mass Spectrometry – Josef Cvačka)
  • NMR spectroscopy with in situ irradiation as a powerful tool to study photochemical processes (NMR Spectroscopy – David Šaman)