Localization of the enzyme 11β-hydroxysteroid dehydrogenase type 1 in mouse colon stained with anti-11HSD1 antibody (A) and negative control (B).
Our research focuses on gastrointestinal (GI) physiology and pathophysiology and on understanding how complex GI functions are influenced by hormonal (corticosteroids) and environmental factors (stress, food, microbiota). Our work uses various strains of rats and mice, including germ-free animals and animal models of colitis and acute and chronic stress. In particular, we address the questions:
- Host - gut microbiome interactions in neuroendocrine regulatory pathways
- Regulation of intestinal transport
- Local metabolism of glucocorticoids
Projects
Publications
Vagnerová; Karla - Jágr; M. - Mekadim; Chahrazed - Ergang; Peter - Sechovcová; Hana - Vodička; Martin - Olša Fliegerová; Kateřina - Dvořáček; V. - Mrázek; Jakub - Pácha; Jiří
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Profiling of adrenal corticosteroids in blood and local tissues of mice during chronic stress
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Scientific Reports. 2023; 13(1)); 7278
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IF = 4.6
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doi
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Soták; M. - Casselbrant; A. - Rath; E. - Zietek; T. - Strömstedt; M. - Adingupu; D. D. - Karlsson; D. - Fredin; M. F. - Ergang; Peter - Pácha; Jiří - Batorsky; A. - Alpers; Ch. E. - Börgeson; E. - Hansen; P. B. L. - Ericsson; A. - Granqvist; A. B. - Wallenius; V. - Fändriks; L. - Unwin; R. J.
Intestinal sodium/glucose cotransporter 3 expression is epithelial and downregulated in obesity
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Life Sciences. 2021; 267(Feb 15)); 118974
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IF = 6.780
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doi
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Pácha; Jiří - Balounová; Kateřina - Soták; M.
Circadian regulation of transporter expression and implications for drug disposition
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Expert Opinion on Drug Metabolism & Toxicology. 2021; 17(4); 425-439
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IF = 4.936
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doi
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Krausová; Alžběta - Burešová; Petra - Sarnová; Lenka - Oyman-Eyrilmez; Gizem - Škarda; J. - Wohl; P. - Bajer; L. - Sticová; E. - Bartoňová; L. - Pácha; Jiří - Koubková; Gizela - Procházka; Jan - Sporrer; M. - Durrbeck; C. - Stehlíková; Zuzana - Vít; M. - Ziolkowska; N. - Sedláček; Radislav - Jirák; D. - Kverka; Miloslav - Wiche; G. - Fabry; B. - Kořínek; Vladimír - Gregor; Martin
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Plectin ensures intestinal epithelial integrity and protects colon against colitis
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Mucosal Immunology. 2021; 14(3); 691-702
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IF = 9.020
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doi
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Ergang; Peter - Vagnerová; Karla - Hermanová; Petra - Vodička; Martin - Jágr; M. - Šrůtková; Dagmar - Dvořáček; V. - Hudcovic; Tomáš - Pácha; Jiří
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The Gut Microbiota Affects Corticosterone Production in the Murine Small Intestine
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International Journal of Molecular Sciences. 2021; 22(8)); 4229
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IF = 6.208
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doi
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Isolated colonic crypt of rat.
Intracellular pH response in isolated colonic crypts of rat. The crypts were exposed to intracellular alkalinization by addition of NH4Cl followed by acidification after washing out the ammonium pulse.