CS / EN
CZ‑OPENSCREEN
National Infrastructure for Chemical Biology
CZ-OPENSCREEN is a state-of-the-art infrastructure for chemical biology and genetics offering open access to potential users. Our mission is to identify new molecular probes and to develop new tools for the research of chemical compounds – candidates for the development of new potential therapeutics.
HIGH-THROUGHPUT SCREENING
Provides comprehensive services encompassing the identification of biologically active compounds by screening of large compound libraries using biological assays and state-of-the-art technologies integrated in robotic systems.
CHEMOSENSITIVE PROFILING
Chemosensitive profiling provides systematic and detailed information about libraries of small compounds or extracts, (e.g.phenotypic changes, cytotoxic and antiproliferative properties), using an extensive panel of cell lines of various histological origin.
MEDICINAL CHEMISTRY
Provides services focused on the synthesis, purification, and structural characterization of new organic compounds with targeted biological activity.
Chemical libraries (or compound collections/sets) are one of the essential components for research areas of chemical biology and medicinal chemistry. Chemical libraries are collections of small organic compounds, usable in drug discovery and other industrial processes.
174,884
DIVERSITY SETS
9,173
BIOACTIVES
7,152
INDUSTRIAL
4,695
ACADEMIC
2,738
NATURAL PRODUCTS
DIVERSITY SETS
~174,448 compounds
wide coverage of chemical space custom compiled sets of chemicals lead-like and drug-like compounds IP-free
ChemBridge Diverse set
25K
Enamine Diverse set
45K
NCI Diversity II
1.4K
EU-OS ECBL Diversity set
99K
BIOACTIVES
9,173 compounds
curated set of tool compounds, chemical probes, and drugs including precompiled commercial libraries from Sigma, Prestwick and Cayman Chemical (prostagnadins and fatty acids)
CZ-OPENSCREEN bioactive set
2.6K
EU-OPENSCREEN bioactive set
2.4K
COMMERCIAL SETS
4.1K
OTHER
~15,000 compounds
proprietary chemical substances donated by academic/commercial research groups commercially inaccessible chemistry
Academic chemistry collection
4.7K
Industrial chemistry collection
7.1K
Natural Products and Extracts
2.8K
CZ-OPENSCREEN provides the services either under open access policy or on the commercial basis, when user pays the full cost of the project. As part of open access cooperation, Material Transfer Agreement is concluded between CZ-OPENSCREEN and the user. Project accepted to the open access program is evaluated by the Open Access Committee.
PROJECT
APPLICATION
OPEN ACCESS
COLLABORATION
FEE FOR SERVICE
PROCESS
User
Open access
Project application
Collaboration
Negotiation / Grant proposal
Fee for service
Expression of interest
CZ-OPENSCREEN
Open access
Project evaluation by OA committee
Collaboration
Negotiation / Grant proposal
Fee for service
Preliminary quote
COSTS
Consumables
Open access
not covered
Collaboration
shared
Fee for service
not covered
Access to tech + FTE
Open access
covered
Collaboration
shared
Fee for service
not covered
Access to compounds
Open access
covered
Collaboration
shared
Fee for service
not covered
LEGAL
IP
Open access
shared
Collaboration
shared
Fee for service
user-owned
Data protection
Open access
Max. 3 years embargo period
Collaboration
negotiable
Fee for service
CDA / proprietary
Contract
Open access
Open Access contract
Collaboration
Grants / Collaborative contracts
Fee for service
Commercial contract